The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Negative Inotropic Effect of Cyclic AMP on the Isolated Canine Heart Muscle
NAOFUMI IWATSUKIKENICHI IWATSUKI
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1973 Volume 110 Issue 4 Pages 409-410

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Abstract
Direct effect of cyclic AMP (c-AMP) on myocardial contractility was investigated in the isolated canine heart muscle. c-AMP at a concentration of 3.3×10-4M produced a decrease in isometric peak force to 75.8% of the control on the average. The result suggests a difference on the effect of exogenous c-AIVLP from that of endogenous one on the contractile behavior of the heart muscle.
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