Abstract
A canine hindlimb muscles prepara-tion is perfused with donor's arterial blood by a peristaltic pump at constant pressure of 100 mmHg. The blood flow and the vascular resistance at rest are 14.3±5.7 (mean±S. D.) ml/min/100g and 7.2±3.6mmHg/ml/min/100g, respectively. Twitch stimulation induces 1.6, 2.2 and 3.8 times increase in blood flow with 1, 2 and 4 contractions per see, respectively. Brief tetanic stimulation, which is composed of 60-msec train of square wave pulses, induces 2.0, 2.2 and 3.0 times increase with 0.2, 0.5 and 1 contraction per see, respectively. Two or 0.4 min of ischemia induces maximum dilatation of the vasculature at rest or during rhythmic contractions, respectively. This dilatation is a little (10-25%) lower than the maximum value following intra-arterial papaverine. Geometric analyses of the recorded curves are performed in reactive hyperemia following 3-min ischemia at rest and during twitch contractions once per sec. Overshot increase of blood flow is 23±6 and 55±17 ml/100 g in each condition, respectively. The indicator which represents duration of the hyperemia is 43±10 and 116±53 sec. The repayment of blood flow is 79±24 and 91±26%. There is no correlation between duration and magnitude of the hyperemia in each condition. There is, however, a good correlation (P<0.001) between the increments of each indicator under both conditions,
