1974 Volume 112 Issue 1 Pages 47-61
The relationship between clinical manifestations and etiologic viruses was discussed based on 23 cases of Japanese children with infectious mononucleosis-like disease. 1) Five cases were caused by cytomegalovirus, 6 caused by Epstein-Barr virus, 2 caused by adenovirus, and 2 caused by a double infection with cytomegalovirus and Epstein-Barr virus. The other 8 cases were caused by unknown etiologic agents. 2) In the group due to cytomegalovirus the onset age was under 1 year, and the frequency of hepatosplenomegaly and liver involvement was high. In the group due to Epstein-Barr virus the onset age was over 1 year, and the frequency of pharyngitis and lymphadenopathy was high. 3) These characteristics of clinical manifestations of the diseases due to both viruses in Japanese children were almost coincident with those of infectious mononucleosis due to Epstein-Barr virus and cytomegalovirus mononucleosis seen in adults in America or Europe.
