抄録
Of 202 gastric cancer cases irradiated preoperatively, 170 were followed up to evaluate irradiation effects. The resectability rate was increased by preoperative irradiation and the five-year survival rate was improved by about 15%. In every cancer stage, the five-year survival rate was higher in the irradiated than in control. Specifically, the comparative irradiated-control rates were 86% vs. 60% of cases in Stage II and 29% vs. 18% of cases in Stage III, showing significant differences at the 5% level. In cases with serosal invasion, the survival rate was particularly higher in the irradiated than in control, and the irradiated had a lower incidence of extraserosal exposure of cancer cells and were associated with markedly better prognosis than control. Cases with greater reactions in stroma besides irradiation-induced destruction of cancer cells and their nests were evidently correlated with a better prognosis. Irradiation-induced fibrosis in stroma seemed to enwrap cancer cells, reforming the “exposed” type to “non-exposed.” These factors seemed to contribute to an improved rate of resectability and better prognosis in our preoperatively irradiated gastric cancer cases.
