The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
113 巻, 1 号
選択された号の論文の8件中1~8を表示しています
  • TOGO HORIUCHI, EIJI ISHIZAWA, YASUYUKI SUZUKI, YOSHIYUKI OKADA
    1974 年 113 巻 1 号 p. 1-15
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Cardiac anomalies in 34 consecutive cases with malposition of the heart were classified according to Van Praagh and surgical treatment was reviewed with special reference to the possibility of total correction. Mirror image-dextrocardia and mesocardia are deemed mostly adaptable to total corrective surgery with the criteria of indication almost identical with VSD or tetralogy of Fallot. Dextrocardia and levocardia in heterotaxy, frequently too complex in malformation, are generally considered inaccessible for total corrective surgery at present. However, total correction may be applicable to some of these cases.
  • HISASHI OHTAKE, TSUNEHIRO NISHIKI, TOSHIHIKO SUZUKI, TEIICHI HOSHINO, ...
    1974 年 113 巻 1 号 p. 17-24
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    During the 13-year-period from 1959 to 1971, a total of 126 cases of malignant lymphoma have been treated at the Department of Radiology, Iwate Medical University. 98 of these cases were reticulum cell sarcoma and they corresponded to 78% of the total cases. Such a high incidence of reticulum cell sarcoma as observed in our series coincides with other reports that pointed out much higher incidence of this disease in Japan than in American and European countries. Staging of cases after Rye classification of Hodgkin's disease revealed that the majority of the reticulum cell sarcoma were in the advanced stage. Crude 5-year survival rates in Stages I, II, III and IV were 54%, 24%, 11% and 0%, respectively. The present results indicated that the combined measure with chemotherapy appears to be effective in Stage III.
  • SUSUMU SAITO, HIRONORI YAMANOBE, SUSUMU TSUKAHARA
    1974 年 113 巻 1 号 p. 25-35
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    A photo-electronic device for analysis of three-dimensional motion of human body without laborious frame by frame analysis of cine film records was constructed in the present study. The apparatus consisted of three photoelectronic units including cylindrical lenses and photoelectronic elements. Each unit gave electrical output signals corresponding to X-, Y- and Z-axis co-ordinates of the target position, respectively. Functional dependence of the output of the unit on the position was linear. The measuring system developed in this study enabled us to measure and record the displacements of human motion in any direction as well as velocity and acceleration components under both static and dynamic conditions.
  • HIROSHI NEMOTO, AKIRA SAKUMA, MASARU HAYAKAWA, TOSHIO SATO
    1974 年 113 巻 1 号 p. 37-52
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Of 202 gastric cancer cases irradiated preoperatively, 170 were followed up to evaluate irradiation effects. The resectability rate was increased by preoperative irradiation and the five-year survival rate was improved by about 15%. In every cancer stage, the five-year survival rate was higher in the irradiated than in control. Specifically, the comparative irradiated-control rates were 86% vs. 60% of cases in Stage II and 29% vs. 18% of cases in Stage III, showing significant differences at the 5% level. In cases with serosal invasion, the survival rate was particularly higher in the irradiated than in control, and the irradiated had a lower incidence of extraserosal exposure of cancer cells and were associated with markedly better prognosis than control. Cases with greater reactions in stroma besides irradiation-induced destruction of cancer cells and their nests were evidently correlated with a better prognosis. Irradiation-induced fibrosis in stroma seemed to enwrap cancer cells, reforming the “exposed” type to “non-exposed.” These factors seemed to contribute to an improved rate of resectability and better prognosis in our preoperatively irradiated gastric cancer cases.
  • GORO KAKIZAKI, TAKAYUKI SAITO, TAKEHIKO SOENO, MASAMI SASAHARA, YOSHIY ...
    1974 年 113 巻 1 号 p. 53-63
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    The parotid saliva test was made on 89 subjects in total, consisting of 54 patients with non-pancreatic disorders, 27 with pancreatic disorders, and 8 remote postoperative cases of pancreatolithiasis, and the following results were obtained: 1) The salivary output as well as the maximum bicarbonate concentration and amylase content in the parotid saliva of patients with pancreatic disorders were significantly less than those of patients with non-pancreatic disorders. 2) Three of the 8 remote postoperative cases of pancreatolithiasis and a case with cancer of the head of the pancreas showed abnormally high salivary output and amylase con-tent. 3) The positive saliva test was found in 85% of patients with pancreatic disorders. 4) Histological changes of the parotid glands were atrophic and degenerative in patients with hypofunction on the saliva test, and hypertrophic in patients with hyperfunction on the saliva test.
  • MASAHIKO ENDO, OSAMU NAMIKI, ZENSAKU YOSIZAWA
    1974 年 113 巻 1 号 p. 65-75
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    The non-dialyzable fractions of glycosaminoglycans and glycoproteins obtained from the urine of one hundred healthy Japanese were determined by gravimetric analysis after fractionation with CPC (cetylpyridinium chloride). 1) Although there was a marked variation in the concentration of these fractions, children showed relatively higher values than adults. 2) The amounts of these fractions in 24-hr urine increased with age in children, but remained constant after puberty. 3) The relative amounts of these fractions, expressed as mg/24-hr urine/kg body weight, increased with age in younger children, and then decreased to an almost constant level in adults. 4) Although the daily excretion of these fractions showed a tendency to be larger in males than in females, no significant difference could be found in the relative amounts between them. 5) The ratios of the glycoprotein fraction to the glycosaminoglycan fraction increased with age in younger children, but remained almost constant after puberty. 6) These observations indicated higher metabolic rate of these substances in children than in adults. Moreover, the data of the group 3 (10_??_14 years of age) showed that it might represent the period of transition between child and adult. 7) Certain correlations were found between the relative amounts of the glycoprotein fractions and those of the glycosaminoglycan fractions in the subjects either below or over 15 years of age. The equation of regression suggested that there might be two groups of glycoproteins in urine. One group was thought to contain the metabolites of the ground substance of the connective tissues, whereas the other seemed to consist of serum glycoproteins and/or glycoproteins of somatic fluids without relation to the connective tissues.
  • TOKIHISA KIMURA, KUNIAKI MATSUI, TATSUO SATO, KAORU YOSHINAGA, TAKESHI ...
    1974 年 113 巻 1 号 p. 77-88
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    Using improved bioassay techniques, plasma concentration of the anti-diuretic hormone (ADH) was determined in thirteen normal subjects, seven patients with chronic renal diseases, and ten patients with central diabetes insipidus. Three different experimental conditions were examined, at two hr after lunch or supper at rest (standard conditions); after overnight restriction of water intake (dehydrated conditions) and after loading excess water (over-hydrated conditions). Osmolality of plasma and urine was also determined. The mean values for ADH concentration in plasma of normal subjects under the standard, dehydrated and over-hydrated conditions were 3.2 ± 0.5, 4.0 ± 0.8, and 0.8 ± 0.2 μU/ml, respectively. Collected data obtained from normal subjects revealed that plasma ADH concentration sharply rose when plasma osmolality exceeded 270 mOsm/kg, but apparent plasma threshold osmolality which caused U/P osmolar ratio of more than unity was around 275-285 mOsm/kg. When compared the ADH levels between standard and dehydrated conditions for individual subjects there were significant increases after the dehydration despite unchanged plasma osmolality, suggesting that some factor or factors other than plasma osmolality may modify the relationship beteen plasma ADH concentration and osmolality. In patients with chronic renal diseases, plasma ADH concentration for the standard and dehydrated states were 3.3 ± 0.9 and 4.9 ± 1.3 μU/ml, respectively. These patients responded to dehydration with an increase in ADH concentration but with much less increase in U/P osmolar ratio. The findings are in accord with the pathophysiological conditions of these patients with impaired renal concentrating capacity without impaired ADH releasing mechanism. In patients with central diabetes insipidus, plasma ADH concentra-tion under the standard and dehydrated states (after 3% decrease in body weight) were 0.4±0.1 and 0.9 ± 0.2 μU/ml, respectively. These patients responded to the dehydration test with a remarkable increase in plasma osmolality (288.6 ± 5.3 to 300 ± 7.3 mOsm/kg) without significant increase in plasma ADH concentration.
  • KOTARO TAKAHASHI, KENICHI IWATSUKI
    1974 年 113 巻 1 号 p. 89-95
    発行日: 1974年
    公開日: 2008/11/28
    ジャーナル フリー
    The effects of pentazocine and fentanyl on the pulmonary hemodynamics were studied in intact anesthetized dogs. Pentazocine produced an increase in pulmonary arterial pressure, which was accompanied with an increase in pulmonary arterial driving pressure, an increase in pulmonary vascular resistance and a decrease in pulmonary vascular compliance. Cardiac output and left atrial pressure remained almost unchanged after pentazocine. These results indicate that the pulmonary hypertension produced by pentazocine is due to its direct vasoconstrictive effect on the pulmonary vascular beds. On the other hand, fentanyl significantly lowered pulmonary arterial pressure as well as its driving pressure with little change in pulmonary vascular resistance and compliance. Cardiac output and mean arterial pressure decreased significantly after fentanyl. These results indicate that the reduction of pulmonary arterial pressure by fentanyl is caused not by its direct effect on the pulmonary vascular beds, but by a decrease in pulmonary blood flow resulting from systemic cardiovascular depression by fentanyl.
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