抄録
The effects of pentazocine and fentanyl on the pulmonary hemodynamics were studied in intact anesthetized dogs. Pentazocine produced an increase in pulmonary arterial pressure, which was accompanied with an increase in pulmonary arterial driving pressure, an increase in pulmonary vascular resistance and a decrease in pulmonary vascular compliance. Cardiac output and left atrial pressure remained almost unchanged after pentazocine. These results indicate that the pulmonary hypertension produced by pentazocine is due to its direct vasoconstrictive effect on the pulmonary vascular beds. On the other hand, fentanyl significantly lowered pulmonary arterial pressure as well as its driving pressure with little change in pulmonary vascular resistance and compliance. Cardiac output and mean arterial pressure decreased significantly after fentanyl. These results indicate that the reduction of pulmonary arterial pressure by fentanyl is caused not by its direct effect on the pulmonary vascular beds, but by a decrease in pulmonary blood flow resulting from systemic cardiovascular depression by fentanyl.
