Effects of Dibutyryl Cyclic AMP on Carbohydrate and Lipid Metabolism

Abstract

The effects of dibutyryl cyclic AMP (D-cAMP) on the carbohydrate and lipid metabolism were studied in dogs. D-cAMP caused a marked elevation in the blood levels of glucose, lactate and pyruvate in association with a decrease in the level of non-esterified fatty acids. These findings indicate that D-cAMP causes an acceleration of glycogenolysis and a reduction of lipolysis. Although excess lactate and L/P did not show significant changes, it should be considered that there may be a possibility of lactic acidosis with the administration of D-cAMP under certain conditions such as tissue hypoxia or liver function disturbance.