The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Low Serum Alpha-l-Antitrypsin Level as a Contributory Factor of Combined Emphysema in Silicosis
KATUHIKO TOKITAKYUHEI IKEDAKUNIAKI KANNOKENICHI SAITOKEIZO CHIYOTANITAKASHI NAKAMURA
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1975 年 117 巻 1 号 p. 61-67

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In order to evaluate low serum alpha- l-antitrypsin level as a contributory factor of combined emphysema in silicotic patients, serum alpha- l-antitrypsin analysis was carried out in 80 patients with silicosis. Low serum alpha-l-antitrypsin level was found in 5 patients. Large opacities were observed roenty genologically in only 1 out of these 5 cases in contrast to 31 of the other 75 cases. Also the suggestive findings for the emphysema were showed in 4 of these 5 cases while such findings were found on their chest X-ray films in only 43 of the other 75 cases. FEV1.0% below 50 were calculated in 3 of the 5 cases, on the contrary in 22 of the other 75 cases. RV above 50% predicted value was showed by all the 5 low antitrypsin patients, in contrast to only 25 of other 74 cases. The silicotic patients with low serum alpha- l-antitrypsin concentration are most likely to have an association with a high incidence of complicated emphysema.
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© Tohoku University Medical Press
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