The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Positive Chronotropic and Negative Inotropic Effects Induced by Potassium Chloride in the Isolated Canine Atrium
SHIGETOSHI CHIBA
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1976 Volume 119 Issue 1 Pages 101-102

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Abstract

The effects of potassium chloride on inotropic and chronotropic activity were investigated in five isolated canine atrium preparations which were suspended in a bath and perfused with arterial blood from the carotid artery of the heparinized support dog. Potassium chloride administered into the cannulated sinus node artery in a dose range of 100 μg-1 mg produced a dose-related negative inotropic and a positive chronotropic effect. These effects were not influenced by treatment with either atropine or propranolol. From these results, it is concluded that potassium has a direct negative effect on atrial contractility and a direct positive effect on atrial rate.

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