The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Increased Peroxidase Activity in Pendred's Syndrome with Hypothyroidism
MAKIKO YAMAMOTOSHINTARO SAITOTOSHZRO SAKURADAKATSUMI YOSHIDAKAORU YOSHINAGA
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1976 Volume 119 Issue 2 Pages 103-113

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Abstract

An 8-year-old boy with goiter and bilateral nerve deafness had a 46% discharge of radioiodine after thiocyanate administration. He was clinically euthyroid. Although the serum total T4 was low (2. 4 μ/100 ml) and TSH was significantly high (181 μ/ml), the serum total T3 was normal (152 ng/100ml). It was considered that the increased release of TSH by the feedback mechanism in response to the low T4 resulted in a quite normal level of serum T3. The thyroid gland demonstrated a low stable iodine content, an increase in MIT/DIT ratio and a decrease in iodothyronine. The thyroglobul n behaved normally in Sephadex G-200 chromatography and immunoreaction. Thyroid tissue exhibited increased peroxidase activity as measured by I3 formation. Increased peroxidase activity may be related to the observed increase in serum level of TSH.

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