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Volume 119 (1976)
- Issue 4 Pages 297-
- Issue 3 Pages 201-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 119, Issue 2
Displaying 1-10 of 10 articles from this issue
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MAKIKO YAMAMOTO, SHINTARO SAITO, TOSHZRO SAKURADA, KATSUMI YOSHIDA, KA ...1976 Volume 119 Issue 2 Pages 103-113
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn 8-year-old boy with goiter and bilateral nerve deafness had a 46% discharge of radioiodine after thiocyanate administration. He was clinically euthyroid. Although the serum total T4 was low (2. 4 μ/100 ml) and TSH was significantly high (181 μ/ml), the serum total T3 was normal (152 ng/100ml). It was considered that the increased release of TSH by the feedback mechanism in response to the low T4 resulted in a quite normal level of serum T3. The thyroid gland demonstrated a low stable iodine content, an increase in MIT/DIT ratio and a decrease in iodothyronine. The thyroglobul n behaved normally in Sephadex G-200 chromatography and immunoreaction. Thyroid tissue exhibited increased peroxidase activity as measured by I3 formation. Increased peroxidase activity may be related to the observed increase in serum level of TSH.View full abstractDownload PDF (1266K) -
MINEKO FUKUSHIMA, SHUJI WATANABE, KATSUJI KUSHIMA1976 Volume 119 Issue 2 Pages 115-122
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAttempts were made to purify the LH-releasing substance extracted from the leaves of Avena sativa by means of two-step chromatographic procedures using a weakly acidic ion-exchange resin (CC-50, type II) and DEAE-Sephadex A-25 (coarse) with successful results. For preliminary fractionation of such starting materials as dried leaves, fresh leaves, and acetone-extracted powder (crude extracts), 5% acetate-buffered active carbon proved to be more effective than starch zone electrophoresis. From its behavior on chromatography with weakly acidic ion-exchange resins as well as Sephadex gel filtration, the active fraction extracted from the leaves of Avena saliva was assumed to be different from the LH-RH present in the hypothalamus. This partially purified material, however, was demonstrated to have an LH-releasing activity by the ovarian ascorbic acid depletion method using Wistar-Imamichi strain rats. Evidence was presented that its site of action is in the adenohypophysis.View full abstractDownload PDF (398K) -
IKUO SUEMORI, JUNICHI YOSHITAKE1976 Volume 119 Issue 2 Pages 123-133
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAntishock effect of N6, O2-dibutyryl cyclic AMP (DBcAMP) was investigated in rats subjected to Noble-Collip drum trauma and compared with effects of hydrocortisone and Trasylol. Results obtained are as follows. 1) Hydrocortisone and Trasylol administered 1 hr before initiating drumming improved the survival rate from traumatic shock with concomitant reducton of levels of acid phosphatase and β-glucuronidase in circulating blood. DBcAMP administered i. p. immediately after trauma also improved the survival rate to the same extent as did Traylol or hydrocortisone, while no inhibitory effects were observed on acid phosphatase and β-glucuronidase. 2) The rectal temperature fell significantly after suffering trauma, and the rats with greater fall in rectal temperature had poorer chance for survival. The fall in rectal temperature was considerably prevented by DBcAMP in a dose of 0.5 mg/100 g body weight (b. w.). 3) DBcAMP induced a rise in plasma insulin level (IRI) and insulin/glucose ratio (I/G) in shock rats, and the elevation in blood lactate/ pyruvate ratio (L/P) and excess lactate otherwise observed after trauma were satisfactorily prevented by DBcAMP administration. It is concluded that the antishock effects of DECAMP primarily resulted from improvements of the intracellular metabolism induced by its easy passage through the cell membrane and its cAMP like action, while any preventive action was not observed against elevation of lysosomal enzymes in the circulating blood.View full abstractDownload PDF (621K) -
YOSHIO GOTO, TAKAYOSHI TOYOTA, MITSUO MASUDA, KANJI KOMATSU, ATSUSHI K ...1976 Volume 119 Issue 2 Pages 135-148
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAge and sex distribution of diabetics, seasonal incidence of diabetes, grade of hyperglycemia, frequency of vascular complications and daily living conditions were studied on 2771 diabetic patients experienced at five clinics. The cases consisted of 1587 male and 1184 female diabetics. The distribution of age of diabetes onset revealed that males predominate among diabetics but females predominate among child diabetics, and that the percentage of child diabetes was extremely low. This pattern was emphasized as characteristic of Japanese diabetic population. Distribution of fasting blood sugar at the diagnosis of diabetes was compared among the age groups of diabetes-onset and the results showed that percentage of the value exceeding 300 mg/100 ml was highest in the under 10 year-onset cases and decreased with age. The frequency of diabetic retinopathy and of ischemic ECG changes was analysed from the view point of age of diabetes onset and also the duration of the disease. The frequency of the retinopathy at the diabetes-onset was zero in the under 10 year-onset cases, 4.2% in the 10s-onset cases and increased with age. The longer the duration of the disease the higher the frequency of the retinopathy was. This increase along with the duration was most remarkable in the 10s- and 20s-onset cases and less remarkable in the 30s-onset cases. The retinopathy was significantly more frequent in female diabetics. Daily activities of the patients were studied by a questionnaire and the analysis of 1022 cases with diabetes of more than three years revealed that cases of patients working uneventfully and/or feeling fit were most frequent among the 30s- or 40s-onset cases and that cases of bed-disability were frequent among the cases whose diabetes was found in their twenties or younger. This study showed that the prognosis of the patients is quite different according to whether their diabetes occurred before or after 30 years of age.View full abstractDownload PDF (877K) -
ICHIJI SUMITOMO, KITSUYA IWAMA, MEGUMI NAKAMURA1976 Volume 119 Issue 2 Pages 149-158
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn urethane-anesthetized rats, neurons responding to electrical stimulation of the optic nerve (ON) with bursts of spikes were searched for in the region of the thalamic reticular nucleus close to the dorsal nucleus of the lateral geniculate body (LGBd). These neurons were identical with those which had been presumed to be inhibitory internerons (I-cells) of LGBd. Conduc-tion velocities of ON fibers innervating I-cells were determined by measuring differences in response latency between stimulations of two separate sites along the contralateral ON. The velocitiy ranged from 1.9 to 7.3 m/sec with an average of 4.6 m/sec, indicating that among the three groups of ON fibers with different velocities, only the slowest group is involved in activation of I-cells. Calculation of synaptic delays revealed that one group of I-cells was excited mono-synaptically and another, disynaptically. Experiments on rats with the visual cortex chronically ablated provided evidence that the disynaptically excited I-cells received ON impulses via axon collaterals of principal cells of LGBd. The region of the thalamic reticular nucleus containing I-cells was found to receive inputs not only from the contralateral but also from ipsilateral ON.View full abstractDownload PDF (569K) -
SHUNZO CHIBA, MASAO UMETSU, TATSURU YAMANAKA, SHOKO HORI, TOORU NAKAO, ...1976 Volume 119 Issue 2 Pages 159-163
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBetween October and December, 1973, an outbreak of epidemic keratoconjunctivitis occurred in a babies home in Sapporo. 28 out of 58 infants and children suffered from the disease. Infection seemed to have been transmitted within a room by hands of nursing staff with spread into other rooms through the dispensary. Clinical manifesta-tion in almost all of the Patients was pseudomembraneous conjunctivitis without apparent corneal opacities. None of them showed systemic symptoms. Virus isolation was attempted from eye swabs of 4 patients between 5 and 8 days after onset of the disease, and adenovirus type 8 was isolated from all of the specimens. It was found that there was no case of subclinical infection by the serologic tests. Consecutive serologic studies revealed a good neutralizing antibody response to adenovirus type 8 in the patients tested.View full abstractDownload PDF (269K) -
TAKASHI MIURA, WAKIO TORINUKI, YOSHIO TANAHASHI1976 Volume 119 Issue 2 Pages 165-169
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAtrophic blanche developed in a 25-year-old man with systemic lupus erythernatosus is reported. A thermographic exarninat. ion was applied to estimate skin temperature, and the temperature was low on areas where lesions were distributed.View full abstractDownload PDF (2248K) -
NORIO SUWA1976 Volume 119 Issue 2 Pages 171-183
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe parameters of some distribution functions for the radius of spherical bodies randomly dispersed in a three-dimensional space can be estimated on a random test plane of unit surface area. In this estimation the set of measured Nao, δ and (δ2) or that of Nλo, λ and (λ2) is used. They are number of circles, arithmetical mean and secondary moment of circle diameters or number of chords delivered by intersection of a test line of unit length with circles, arithmetical mean and secondary moment of chord length, respectively. Provided that the region of measurement is sufficiently large, intraregional errors of these quantities expressed as the squares of coefficient of variation C are approximately: [C(Nao)]w2=1/Nao, [C(δ)]w2=(32/3π2)(Q3/Q22)(1/Nao) and [C(δ)]w2=(6/5)(Q5/Q32)(1/Nao); [C(Nλo)]w2=1/MNλo, [C(λ)]w2=(9/8)(Q4Q2/Q32)(1/MNλo) and [C(λ)]w2=(4/3)(Q6Q2/Q42)(1/MNλo). In these expressions Qn is a quotient defined by (Dn)/Dn, D and n being sphere diameter and a positive integer, respecitvely. The first three expressions may be used in these forms as the errors for the total region containing spheres. In the second three expressions M is the number of random test lines of unit length. When M is small, they can stand for the errors of the total region. In the case of large M, however, interregional errors or errors of sampling have to be added to them. The geometrical parameter of a distribution function of D is estimated from (δ2)/δ2 or (λ2)/λ2. The error of this ratio W is given by: [C(W)]2=[C(X2)-2C(X)]2, where X stands for δ or λ.View full abstractDownload PDF (637K) -
NORIO SUWA1976 Volume 119 Issue 2 Pages 185-195
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe parameters of some distribution functions for the radius of spherical bodies randomly dispersed in a three-dimensional space can be estimated with a grating of parallel test lines of regular intervals superposed on a test plane of unit surface area. The interval of the test lines is set narrower than the mean diameter of the circles on the test plane. The errors of number Nλo of chords per test line of unit length, arithmetical mean A and secondary moment (λ2) of the length of individual chords are: [C(Nλo) *]2=(4/9π)(Q3/Q22)(1/M2λ, Nλo)+(4/π)(λ/Nλo), [C(λ)*]2=(π/4)[(32/3π2)-1] (1/M2λNλo) + [(4/π)-(3π/8)(Q22/Q3)](λ/Nλo) and [C(λ2)*]2=(1024/2025π)(Q5Q3/Q42) (1/M2λNλo)+4[(4/π)-(3π/8)(Q22/Q3
)](λ/Nλo). The first and second terms of the right sides of these expressions represent intraregional and interregional errors, respectively; * denotes the error for the total region; M is the expectation of the number of test lines of unit length covering the test plane; and Qn a quotient (Dn)/Dn of sphere diameter D, n being a positive integer. Intraregional errors are inversely proportional to M2 with the grating, while they are inversely pro-portional only to M with random test lines. The use of regularly arranged test lines is consequently effective in minimizing intraregional errors.View full abstractDownload PDF (504K) -
TETSURO ABE, NOBUAKI FURUHASHI, ICHIO OHASHI, MASAKUNI SUZUKI1976 Volume 119 Issue 2 Pages 197-200
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to screen the neurotics and non-neurotics of climacteric women with menopausal symptoms, conjugated estrogen was injected intravenously and the reactions were compared. Menopausal symptoms were represented by Kupperman's menopausal index. After estrogen injection the non-neurotics showed a decrease of the index, i. e., alleviation of the symptoms, while the neurotics showed no change of the index. Taking advantage of this difference, a discriminant function be-tween neurotics and non-neurotics was calculated using, as variables, Kupperman's menopasual indices determined before and after administration of the conjugated estrogen. The calculative screening obtained from this discriminant function yielded consistency with clinical diagnosis in about 94% of the neurotics and about 87% of the non-neurotics, suggesting that this test is of value in the screening of neurotics and non-neurotics in the climacteric women with menopausal symptoms.View full abstractDownload PDF (216K)
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