Colony-Forming Cells in Culture and Colony-Stimulating Activity of the Urine and the Serum in a Case of Cyclic Neutropenia

HIDEAKI MIZOGUCHI; SHIN CHIYODA; YASUSADA MIURA; FUMIMARO TAKAKU; SHIGETAKA ASANO; SHIGETOH SUZUKI; AKIO URABE; SHOZO CHIBA; KINORI KOSAKA; SHIRO MIWA

doi:10.1620/tjem.119.317

HIDEAKI MIZOGUCHI, SHIN CHIYODA, YASUSADA MIURA, FUMIMARO TAKAKU, SHIGETAKA ASANO, SHIGETOH SUZUKI, AKIO URABE, SHOZO CHIBA, KINORI KOSAKA, SHIRO MIWA

Author information

HIDEAKI MIZOGUCHI
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
Division of Ho]emopoiesis, Institute of Hematology, Jichi Medical School
SHIN CHIYODA
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
Division of Ho]emopoiesis, Institute of Hematology, Jichi Medical School
YASUSADA MIURA
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
Division of Ho]emopoiesis, Institute of Hematology, Jichi Medical School
Department of Medicine, Jichi Medical School
FUMIMARO TAKAKU
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
Department of Medicine, Jichi Medical School
SHIGETAKA ASANO
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
SHIGETOH SUZUKI
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
AKIO URABE
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
SHOZO CHIBA
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
KINORI KOSAKA
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
SHIRO MIWA
The Third Department of Medicine, Faculty of Medicine, University of Tokyo
Department of Medicine, University of Yamaguchi

Keywords: cyclic neutropenia, colony-forming cells

JOURNAL FREE ACCESS

1976 Volume 119 Issue 4 Pages 317-324

DOI https://doi.org/10.1620/tjem.119.317

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Abstract

A 22-year-old female with cyclic neutropenia was studied. Her bone marrow cells showed high colony-forming activity in soft agar through the cycle, though there were slight fluctuations in the number and the shape of colonies. On the other hand, the peak of urinary colony-stimulating activity (CSA) occurred at the neutropenic stage. The dialyzed serum showed two peaks of CSA, i. e., at the peak and the valley of the neutrophil count, although the undialyzed serum showed only one peak at the neutropenic stage. It is suggested on the basis of these data that humoral factors may play a role in maintaining the neutrophil cycle.

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