Abstract
In some of the experiments quoted in the previous paper, the indican formation in nephritis was decreased apparently, but the indican in urine and blood was estimated at that time only. Strictly speaking, however, we can not comment on the total amount of produced indican without consideration of the indican in the tissues and organs. Actually, at present we are able to insist that the indican formation increases in nephritis invariably, on the basis of experiments, in which the indican retained in the body has been estimated and added to the indican excreted in reckoning the total amount of produced indican.
Here I repeat my proposal: Between the indican formation in an organism and the state of appetite there exists an intimate relation, and when the appetite decreases the amount of indican increases and vice versa. Now I have reached the conclusion that my this proposal is applicable in the case of nephritis as well as in other cases, and it is my belief that the fact that indican increases when the appetite decreases means no more than that indican is produced from body protein.
