The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
An IgG M-Component Reacting with Both Anti-κ and Anti-λ Light Chains in Multiple Myeloma
SEIJU ONODERA, RYUTARO INABA, ISAO SATO, KAZUYASU ENDO, TAKASHIRO SUZUKI, OSAMU KITAHARA, KATSUKO TAKAIIASHI, SHIGEO SUZUKI, YUKIO IMAMURA
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Keywords: multiple myeloma, IgG-IM component, reaction with both Anti-κ and anti-λ
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1976 Volume 120 Issue 3 Pages 269-275

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Abstract
A patient with multiple myeloma who has an IgG-IM-component in serum reacting with both κ and λ light chains in im-munoelectrophoresis is presented. The possibility of ‘hybrid molecule (H2LκL λ)’ is strongly suspected. The absorption studies of the patient's serum employing Anti-κ and anti-A light chains, however, support the view that this apparently single M-component consists of two M-components, IgG 1-κ and IgG 1- λ. The reason why these two M-components possessed the identical electrophoretic mobility is unclear. The possibility is high that these two M-components are produced in the same cell.
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