The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Experimental Pulmonary Emphysema in Syrian Hamsters
TOSHIO NAKAMURA, TADAO ISHIKAWA, TAKASHI NIWA, FUMIO ARIJI, TAKASHI MATSUDA, NOBORU ASOO, HIROMI NAGAI, HIDEO ARAI, ATSUNOBU YOKOSAWA, HIROSI SATO, MASAKICHI MOTOMIYA, KIYOSHI KONNO
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キーワード: pulmonary emphysema, hamster, proteolysis
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1976 年 120 巻 4 号 p. 319-327

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Syrian hamsters were exposed to the aerosol of a 5% solution of papain in the presence of cysteine and ethylenediamine-tetraacetic acid. Pulmonary emphysema in hamsters was observed after exposure to papain for two to three hours. There was no change with time in the severity of emphysema from the second through the fourth weeks after exposure to papain. Pathogenesis of pulmonary emphysema was discussed in relation to proteolysis of glycosaminoglycan-protein complex.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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