The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
A Comparative Study of the Effect of Vitamin E-Nicotinate and the Combination of Vitamin E and Nicotinic Acid on the Hydrogen Peroxide-Induced Platelet Aggregation
OTOTAKA HIGASHI, YOKO KIKUCHI
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Keywords: hydrogen peroxide, vitamin E, vitamin E-nicotinate, platelet aggregation
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1977 Volume 121 Issue 1 Pages 81-84

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Abstract

The inhibitory effect of vitamin E-nicotinate upon the hydrogen peroxide (H2O2)-induced platelet aggregation was found to be greater than that of either vitamin E alone or the combination of vitamin E and nicotinic acid. Nicotinic acid showed no inhibitory effect. It was suggested that the effect of vitamin E-nicotinate was not due to the additive effect of vitamin E and nicotinic acid produced by hydrolysis, but to the unique and distinctive property of vitamin E-nicotinate itself.

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