Inherited Chromosomal Translocation in Two Families (t(4q-; 13q+) and t(5q-; 13q+))

Abstract

Two families with reciprocal translocations, t(4q-; 13q+) and t(5q 13q+), are reported. Each proband carried multiple malformations resulting from the unbalanced segrega-tion in two mothers of balanced carriers. The karyotype-phenotype relationship is discussed with reference to other previously reported cases of B/D translocation.