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Volume 121 (1977)
- Issue 4 Pages 301-
- Issue 3 Pages 197-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 121, Issue 2
Displaying 1-14 of 14 articles from this issue
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TAKAYOSHI TOYOTA, MIKIHIKO KUDO, KANJI ABE, YOSHIO GOTO1977 Volume 121 Issue 2 Pages 99-104
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt is one of the characteristic features in diabetes mellitus that insulin response to glucose is low. Nine low insulin responders with normal glucose tolerance in whom prediabetes inellitus should be suspected were found to be included in 104 apparently healthy subjects (9%). A 100g glucose tolerance test (GTT) was performed in nine apparently healthy subjects with aa low insulin response and 11 healthy subjects with a normal insulin response. A 50g GTT was performed in 15 normal subjects, 20 subdiabetics, 38 chemical diabetics and 17 mild diabetics. In all subjects C-peptide during GTT was estimated by the double antibody systems using a synthetic human C-peptide. Though C-peptide secretion from the beta cell of the pancreas seems to keep pace with insulin secretion, the peak of, C-peptide was delayed in its appearance in the circulating blood, as compared with-that of insulin. The pattern of plasma C-peptide during GTT in diabetics was identical with that of insulin. In the low insulin responders C-peptide response to glucose was observed to be lower like that of insulin than in the normal insulin responders. However, a molar ratio of C-peptide to insulin at 30 min during GTT in the former was higher than that in the latter.View full abstractDownload PDF (345K) -
RUBENS MOREIRA ARCIERI, CELSO MARTINELLI1977 Volume 121 Issue 2 Pages 105-110
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe influence of extirpation of the subrnandibular and sublingual, parotid and all major salivary glands on pregnancy of rats was studied. The statistic analysis of the results indicated that there are statistically significant differences in the number of offsprings between before and after extirpation of the salivary glands. The parotidectomized female rats presented the smallest number of offsprings as compared with other groups and presented some progressive sterility after the gland extirpation.View full abstractDownload PDF (343K) -
MASAHIDE SEINO, KEISHI ABE, YUTAKA SAKURAI, NOBUO IROKAWA, MINORU YASU ...1977 Volume 121 Issue 2 Pages 111-119
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUrinary kallikrein excretion was measured before and after administration of spironolactone in 12 patients with essential hypertension (including 7 patients with low renin and 5 patients with normal renin) and 6 patients with primary aldosteronism. In low renin essential hypertension, two types of urinary kallikrein excretion were observed. In one type, urinary kallikrein decreased from 6.2±2.1 (S. E.) EU/day to 2.7±0.3 EU/day after the treatment. In another type. urinary kallikrein increased from 3.1±0.5 EU/day to 6.4±1.0 EU/day. In the former, plasma aldosterone showed high levels (12.3±2.1 ng/100 ml), while in the latter, it was normal (3.2±0.5 ng/100 ml). In normal renin essential hypertension, urinary kallikrein excretion did not alter after the treatment. In primary aldosteronism, urinary kallikrein showed moderate decrease after the spironolactone treatment from 8.5±1.6 EU/day to 4.2±1.6 EU/day. Spironolactone is said to compete directly with the effect of aldosterone at renal distal tubules. The present investigation suggests that urinary kallikrein excretion is related to the effective levels of aldosterone at renal distal tubules, and alteration of aldosterone levels mediates the release of kallikrein, and that there are different mechanisms in the renal handling of sodium and kallikrein in low renin essential hypertension, in normal renin essential hypertension, and in primary aldosteronism,View full abstractDownload PDF (567K) -
AKIRA WAKIZAKA, EIJI OKUHARA1977 Volume 121 Issue 2 Pages 121-126
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe antigenic determinant of thermally denatured salmon sperm (ss) DNA was extensively investigated with a radioimnnmoassay technique using the ssDNA immune system. It was demon-strated that mixed sequences of purines and pyrimidines play a key role in the antigenic determination of DNA. On the other hand, the importance of the bases in the manifestation of DNA antigenicity was demonstrated by using brominated, methylated and/or ultraviolet irradiated ssDNA preparations.View full abstractDownload PDF (292K) -
AKIRA WATANABE, HISAAKI HANAZONO, HIDEAKI SOGAWA, HIKOICHIRO TAKAYA1977 Volume 121 Issue 2 Pages 127-131
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA 14-year-old boy with ataxia-telangiectasia died of pneumonia, stomach cancer and its diffuse metastasis. The onset of waddling gait was noticed from 3 years of age. Immune globulin including IgA was normal or slightly increased. Main autopsy findings were : old cancerous ulcer of 1.4×2.3cm at the lesser curvature, and diffuse cancer infiltration over ulcer surface to serous membrane. The tumor was diagnosed histologically as adenocareinoma tubulare mucocellulare. ataxiaView full abstractDownload PDF (2165K) -
SEIGI TSUCHIDA, OSAMU YAMAGUCHI1977 Volume 121 Issue 2 Pages 133-141
Published: 1977
Released on J-STAGE: November 30, 2010
JOURNAL FREE ACCESSTSUCHIDA, S. and YAMAGUCHI, O. A Constant Electrical Activity of the Renal Pelvis Correlated to Ureteral Peristalsis. Tohoku J. exp. Med., 1977, 121 (2), 133-141-Using a bipolar macroelectrode, simultaneous recordings of both pelvic and ureteral electromyograms (EMG) were carried out in dogs. The recordings were performed at 3 stages of urine flow; oliguric, increasing and diuretic stages. The results showed that the interval of the pelvic discharge was constant while its speed of propagation was slower than that of the ureter (1.32 cm/sec and 2.12 cm/sec, respectively). At oliguric stage the interperistaltic interval in the ureter constituted a multiple of the pelvic discharge interval. Ureteral peristaltic rate reached that of the renal pelvis with increasing urine flow. These results are discussed in relation to a hypothesis of a renal pelvic pacemaker. pelvic electromyography; ureteral peristalsis; pacemakerView full abstractDownload PDF (916K) -
MASAYOSHI GOTO, TETSUO KIMURA, HARUO SATO, SIGEO SUZUKI, MASAKO SUZUKI ...1977 Volume 121 Issue 2 Pages 143-148
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEffect of polyanions on saturation density and production of viscous substance of cells of mouse and hamster cell lines was studied. Cell lines used were 3T6, HA-2 and HA-8 cells. Polyanions were dextran sulfate, (3, 6-anhydro-4-o-β-galactopyranosyl-2-D-galactopyranose-2, 4'-bis (potassium/sodium sulfate) (1→3) polysaccharide (polygeenan) and dextran phosphate. Dextran sulfate reduced the saturation densities of cell lines. Growth of 3T6 cells was not significantly affected by dextran sulfate. Polygeenan and dextran phosphate could not decrease the saturation densities of all the cell lines tested. The production of viscous substance into medium from the treated cells increased after treat-ment with all polyanions with the exception of dextran phosphate of molecular weight 40, 000. It was suggested that specific structure of polyanion might be necessary for the decrease of saturation density of cell lines. Furthermore, it appears that dextran sulfate decreases saturation density of cell line along with change of phenotypic expression of cells.View full abstractDownload PDF (461K) -
KOZUI MIYAZAWA, KUNIO SHIRATO, TAKASHI HANEDA, TAKAO HONNA, TORU ARAI, ...1977 Volume 121 Issue 2 Pages 149-156
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn 13 open chest dogs, the right atrium and various ventricular sites (i. e. the inflow and outflow tracts and apex of the right ventricle, apex and lateral wall of the left ventricle) were stimulated electri-cally at a given rate, ranging from 140 to 210 per min. Coronary circulation and cardiodynamics in response to ventricular pacing were compared with those to right atrial pacing at equivalent heart rate. Stimulation of the ventricle except lateral wall of the left ventricle produced no significant changes in coronary sinus blood flow and myocardial oxygen consumption despite decreased blood pressure and cardiac output. The minor change of coronary sinus blood flow was related to the decrease in coronary vascular resistance. Oxygen content of coronary sinus blood decreased during ventricular pacing, while arterial oxygen saturation remained constant. The response of coronary circulation to ventricular pacing did not differ essentially at faster and slower heart rates. It was considered that when stimuli were applied to the ventricular surface, the relatively constant myocardial oxygen consumption in the presence of lowered cardiac performance was attributed to the asynchrony of fractionate contractions of the ventricular muscle, coronary circulation;View full abstractDownload PDF (818K) -
TETSURO KATO, ROBERT J. IRWIN, Jr., GEORGE R. PROUT, Jr.1977 Volume 121 Issue 2 Pages 157-164
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCell cycle analysis was performed on two established cell lines of human bladder transitional carcinoma, MGH-I71 and T24 cells. The cells were cultured on round cover slips for three days, autoradiograms were prepared after pulse-labeling with 3H-TdR and the fractions of labeled mitoses (FLM) were calculated every 2 hours through 36 hours. The FLM curves were analyzed by the empirical half-height level method as well as Mendelsohn-Takahashi's asymmetry method Which is a global type of FLM analysis based on Takahashi's generalized model. The results did not show any distinct differences in the cell cycle parameters between MGH-U1 and T24 cell lines. A remarkable discrepancy, however, was observed between the cell cycle times analyzed by the asymmetry method and by the half-height level method. Although there is no evidence that the asymmetry method is biologically correctt up to now, Mendelsohn and Takahashi tested this method repeatedly and mathematically proved that it had much less error than that of the tranditional boundary method.View full abstractDownload PDF (1051K) -
HISAKO SASAKI, YASUHIKO HASHIMOTO, KENICHI IWATSUKI1977 Volume 121 Issue 2 Pages 165-172
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of ether, halothane and me-thoxyflurane (0.5-1.5 MAC) on renal blood flow and its autoregulation were studied in 24 dogs. The left renal artery was perfused with the animals' own blood by a constant pressure perfusion system. The perfusion pressure ranged from 60 to 200 mmHg. Renal blood flow at the perfusion pressure of 100 mmHg was changed neither by ether nor by halothane, while it was decreased dose-dependently by methoxyflurane. At equipotent anesthetic concentrations the autoregulation of renal blood flow was only slightly impaired by ether, but significantly by halothane and methoxyflurane. Adenosine (100 μg/min) or calcium chloride (10 mg/min) which was infused directly into the renal artery resulted in a restoration of autoregulation impaired by MAC -1 of each anesthetic whenn perfusion pressure was raised stepwise from 100 to 200 mmHg, but no restoration was observed at low perfusion pressure below 100 mmHg. The results indicate that methoxyflurane exerts a direct constrictive effect on the renal vasculature. Adenosine and calcium may play a significant role on the response of the renal vasculature to raised perfusion pressure.View full abstractDownload PDF (449K) -
TOKUTARO SATO, TSUYOSHI SAITO, MASARU KOKUBUN, MASAAKI ITO, KAORU YOSH ...1977 Volume 121 Issue 2 Pages 173-178
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA new method for colorimetric determination of urinary hydroxylysine is described. Approximately one-hundredth of human urine collected for 24 hr was diluted to 25ml and titrated to pH 2.0 with 2 N HCl, and then subjected to column chromatography on Dowex 50×4 (H+ form). Amino acids were eluted from the column with 1.5 N NH4OH. Hydroxylysine in the eluate with 1.5 N NH, OH was separated from the other amino acids, especially from serine and threonine, by preparative paper chromatography. The paper corresponding to hydroxy-lysine was cut and eluted with water. An aliquot of the eluate with water was oxidized by sodium metaperiodate, and formaldehyde liberated from hydroxylysine was assayed by chromotropic acid reagents, after removing periodate and iodate with Dowex 1×8 (formate form). Excretion rate of hydroxylysine in urine of adults was shown to be approximately 110 μmoles per day. urinary hydroxylysineView full abstractDownload PDF (764K) -
GENTARO WATANABE, YOKO KIYOI, ISAO TAKEYAMA, SEIJI KAWANA, MASAHARU YA ...1977 Volume 121 Issue 2 Pages 179-184
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTwo families with reciprocal translocations, t(4q-; 13q+) and t(5q 13q+), are reported. Each proband carried multiple malformations resulting from the unbalanced segrega-tion in two mothers of balanced carriers. The karyotype-phenotype relationship is discussed with reference to other previously reported cases of B/D translocation.View full abstractDownload PDF (938K) -
KUNIAKI NARISAWA, YOSHIRO WADA, TAKASHI SAITO, HIROSHI SUZUIKI, MASAFU ...1977 Volume 121 Issue 2 Pages 185-194
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTwo infants of homocystinuria with a defective activity of the N5, 10-Methylenetetrahydrofolate reductase in the liver, kidney, brain and/or leukocytes were reported. Contrary to four cases with similar biochemical defects reported up to date, the two cases of ours demonstrated peculiar clinical features charact-erized by an early onset in infancy, fits of apnea and seizures, downhill course with coma, and death within one year of life. Thus “an infantile type” of this disorder was advanced as a new clinical entity. Assay for the N5, 10-methylenetetra-hydrofolate reductase activity using peripheral leukocytes was established and might be useful for a diagnosis of this disorder and also for detection of hetero-zygotes.View full abstractDownload PDF (1153K) -
MAKOTO TAKAHASHI, SUETSUGU MUE, TETSUHIRO OHMI, SHIGEKI SHIBAHARA, KOH ...1977 Volume 121 Issue 2 Pages 195-196
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing hippuryl-L-histidyl-L-leucine as a substrate analog, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma. There were significantly low activities of serum ACE in 115 patients with bronchial asthma irrespective of the presence or absence of acute attack. The activity of serum ACE was reduced more markedly in the chronic type of bronchial asthma than in the paroxysmal type.View full abstractDownload PDF (122K)
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