Cell-Mediated Immunity to Measles Virus in Subacute Sclerosing Panencephalitis

TATSURU YAMANAKA; SHUNZO CHIBA; TOORU NAKAO; NOBUHIKO OKABE; NOBUO TAKAHASHI; SETSUKO SAITO; TOORU KITAYAMA; HIROSHI MISHIMA; KANAHIRO KONNO; KAZUE FUJIWARA

doi:10.1620/tjem.122.175

TATSURU YAMANAKA, SHUNZO CHIBA, TOORU NAKAO, NOBUHIKO OKABE, NOBUO TAKAHASHI, SETSUKO SAITO, TOORU KITAYAMA, HIROSHI MISHIMA, KANAHIRO KONNO, KAZUE FUJIWARA

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TATSURU YAMANAKA
Department of Pediatrics, Sapporo Medical College
SHUNZO CHIBA
Department of Pediatrics, Sapporo Medical College
TOORU NAKAO
Department of Pediatrics, Sapporo Medical College
NOBUHIKO OKABE
Department of Pediatrics, Tokyo Jikei Medical College
NOBUO TAKAHASHI
Department of Pediatrics, Tokyo Jikei Medical College
SETSUKO SAITO
Department of Pediatrics, Kanto Teishin Hospital
TOORU KITAYAMA
Department of Pediatrics, Tokyo Jikei Medical College
HIROSHI MISHIMA
Department of Pediatrics, Fukushima Medical College
KANAHIRO KONNO
Department of Pediatrics, Fukushima Medical College
KAZUE FUJIWARA
Department of Neurosurgery, Tokyo Bokuto Hospital

Keywords: cell-mediated immunity, SSPE, lymphocytotoxicity

JOURNAL FREE ACCESS

1977 Volume 122 Issue 2 Pages 175-181

DOI https://doi.org/10.1620/tjem.122.175

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Abstract

Four patients with subacute sclerosing panencephalitis were investigated for their specific cellular and humoral immunities against measles virus. Lymphocytotoxicity mediated by peripheral blood lymphocytes was evaluated with the colony inhibition test of target cells having measles antigen. The lymphocytes from two patients of subacute sclerosing panencephalitis (SSPE) specifically destroyed the carrier cells; however, no significant lymphocytotoxicity was observed in the other two patients. The result suggests the heterogeneity in cellular immune states in SSPE patients.

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