The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Factors Influencing the Release of Renin in Patients under Chronic Dialysis Treatment
HIROSHI KANEDA, MASATO TASHIRO, TOYOAKI MURATA, JUN MATSUMOTO, MUTSUO TAKEUCHI, TAKECHI HARUYAMA
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Keywords: PRA in dialysed patients, releasability of renin and dialysis treatment
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1979 Volume 129 Issue 2 Pages 177-182

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Abstract

Plasma renin activities (resting PRA, post-dialysis PRA and JPRA) were studied in 61 patients under chronic dialysis treatment. Removed sodium and removed water were estimated at each dialysis. ΔPRA/removed-sodium and ΔPRA/removed -water were calculated as indices in response to the removal of sodium and water during the dialysis. 1) Resting PRA (pre-dialysis PRA) was positively correlated to ΔPRA/removed-sodium, ΔPRA/removed-water, serum osmolality, and diastolic blood pressure, but negatively to serum sodium concentration, age, and pulse pressure/diastolic blood pressure. Statistically significant factors controlling the resting PRA were ΔPRA/removed-sodium, ΔPRA/removed-water, and serum sodium concentration. Resting PRA was slightly correlated to diastolic blood pressure and age. 2) Post-dialysis PRA was significantly correlated to the resting PRA, ΔPRA/removed-sodium, ΔPRA/removed-water, serum sodium concentration, and age, but not to the blood pressure indices.

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