The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Neuromuscular Blocking Property of Minocycline in the Rabbit
YASUHIKO HASHIMOTO, TAKESHI SHIMA, SHUN MATSUKAWA, KENICHI IWATSUKI
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Keywords: minocycline, neuromuscular transmission
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1979 Volume 129 Issue 2 Pages 203-204

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Abstract

The neuromuscular blocking property of minocycline hydrochloride (MNC) was studied in 12 rabbits. In 2 of 6 animals, MNC, 60-160mg/kg, alone caused a decrease in twitch tension. During partial neuromuscular blockade produced by a continuous infusion of pancuronium, the intravenous administration of MNC, 20-60mg/kg, resulted in a dose-dependent decrease in twitch tension in 6 animals. MNC-induced or combined MNC-pancuronium-induced neuromuscular blockade was antagonized by calcium or by neostigmine.

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