抄録
IgG immune deposits in glomerular lesions were found in 62% of 4-week-old mice born from anti-DNA antibody positive mothers but not in the mice born from anti-DNA antibody negative ones. In the former mice anti-DNA antibody producing cells could not be detected in spite of the presence of antibody. These results indicate that maternal anti-DNA anti-body might be responsible for the development of glomerular lesions in the offspr-ings. Renal lesions, however, was not observed in the 2- to 3-month-old mice indicating that permanent lesions were not induced by this transient maternal antibody.
