The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Acidic Glycosaminoglycans in Cultured Skin Fibroblasts of a Patient with Epidermolysis Bullosa Dystrophica Dominans
MINORU IGARASHI, MAKOTO SEIJI
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Keywords: epidermolysis bullosa dystrophica, acidic glycosaminoglycans, hyaluronic acid, dermatan sulfate
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1980 Volume 130 Issue 2 Pages 207-208

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Abstract
A biochemical study was carried out on acidic glycosaminoglycans in the cultured skin fibroblasts obtained from a patient with epidermolysis bullosa dystrophica dominans. Acidic glycosaminoglycans were separated from fibroblasts and medium, and subjected to quantitative and qualitative analyses by cellulose acetate membrane electrophoresis, column chromatography and gel filtration. It was found that hyaluronic acid and dermatan sulfate were slightly increased in epidermolysis bullosa dystrophica dominans in comparison with the normal control.
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