抄録
During 6 years from 1971 to 1976, 7 patients with pulmonary atresia or pseudotruncus arteriosus had undergone various shunt operations at Tohoku University Hospital; the survival rate was only 29%. There were difficulties in the pre- and post-operative management of the cases because of their deteriorated life conditions caused by PDA closure before the operation. Since the summer of 1976, we have experienced another 8 cases of such anomalies and administered prostaglandin-E1 to 5 of them as a non-surgical palliation before the shunt operation. Prostaglandin-E1, 0.01-0.1 μg/kg/min, was given intrave-nously with a micro-drip technique. The administration was followed by im-mediate and significant rise in PaO2, and SaO2. As a side effect, periodic apnea was observed. Respiratory management is indispensable in using prostaglandin-E1. This technique seems to be an effective treatment for such patients as a non-surgical palliation.
