Gluconeogenesis from Glycerol and Alanine in Thyrotoxicosis

Abstract

Gluconeogenesis in thyrotoxicosis was studied by oral glycerol-loading test and alanine-loading test performed on 5 normal subjects and 5 cases of thyrotoxicosis. The blood glucose levels in thyrotoxicosis rose after the administration of glycerol deposite elevation of the plasma levels of insulin. After the administration of alanine, the levels of IRI, pyruvate and lactate elevated in thyrotoxicosis. In normal subjects, the plasma levels of glucose, IRI, pyruvate, or lactate did not change significantly after glycerol or alanine load.