Abstract
ISHIHARA, Y. and KITAMURA, S. Effect of Heparin Na on the Action of Various Bronchoconstrictors in Guinea Pig Tracheal Strips. Tohoku J. exp. Med., 1981, 133 (1), 61-65-The effect of heparin Na on the actions of various bronchoconstrictors was examined. Guinea pig tracheal strips were suspended in bioassay glass chambers and superfused with Krebs-Henseleit solution, pH 7.4, at 37°C saturated with oxygen and carbon dioxide gas (95:5, v/v). Contraction of the tissue was detected by an isotonic transducer and displayed on a polyrecorder. Heparin Na attenuated histamine-, prostaglandin F2α, acetylcholine-, serotonin-induced contractile responses does-dependently, and shifted the dose-response curves of histamine, prostaglandin F2a, acetylcholine, serotonin and bradykinin downward.
