Effect of Heparin Na on the Action of Various Bronchoconstrictors in Guinea Pig Tracheal

Abstract

ISHIHARA, Y. and KITAMURA, S. Effect of Heparin Na on the Action of Various Bronchoconstrictors in Guinea Pig Tracheal Strips. Tohoku J. exp. Med., 1981, 133 (1), 61-65-The effect of heparin Na on the actions of various bronchoconstrictors was examined. Guinea pig tracheal strips were suspended in bioassay glass chambers and superfused with Krebs-Henseleit solution, pH 7.4, at 37°C saturated with oxygen and carbon dioxide gas (95:5, v/v). Contraction of the tissue was detected by an isotonic transducer and displayed on a polyrecorder. Heparin Na attenuated histamine-, prostaglandin F_2α, acetylcholine-, serotonin-induced contractile responses does-dependently, and shifted the dose-response curves of histamine, prostaglandin F_2a, acetylcholine, serotonin and bradykinin downward.