The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Probable Superoxide Therapy of Experimental Cancer with D-Penicillamine
SHINICHI OKUYAMA, HITOSHI MISHINA
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Keywords: superoxide therapy, experimental cancer, D-penicillamine
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1981 Volume 135 Issue 2 Pages 215-216

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Abstract

OKUYAMA, S. and MISHINA, H. Probable Superoxide Therapy of Experimental Cancer with D-Penicillamine. Tohoku J. exp. Med., 1981, 135 (2), 215-216-A sublethal dose of D-penicillamine (DP) induced hyperlipoperoxidemia and hypocupremia in old rats. Treatment of cancer cells in vitro and in vivo with DP resulted in appreciable suppression of cell multiplication and a remarkable inhibition of tumor growth. Erythropoiesis did not seem to be affected by DP. The selective effect of DP seems to have resulted from the reduced superoxide dismutase activity and/or defective Mn superoxide dismutase.

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