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Volume 135 (1981)
- Issue 4 Pages 335-
- Issue 3 Pages 219-
- Issue 2 Pages 117-
- Issue 1 Pages 1-
Volume 135, Issue 2
Displaying 1-12 of 12 articles from this issue
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TAMOTSU TAKISHIMA, WATARU HIDA, SHUNSUKE SUZUKI, TAKAO SASAKI1981 Volume 135 Issue 2 Pages 117-137
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKISHIMA, T., HIDA, W., SUZUKI, S. and SASAKI, T. Direct Graphical Recordings of the Cumulative Dose-Response Curves of the Airway to Methacholine in Normal, Bronchitic and Asthmatic Subjects. Tohoku J. exp. Med., 1981, 135 (2), 117-137-We studied bronchial responsiveness to methacholine in 10 normal subjects, in 60 patients with bronchial asthma and in 30 patients with bronchitis using a new device, with which we were able to obtain the dose-response curve of respiratory resistance (Rrs) continuously and graphically by the 3Hz oscillation method during inhalation of methacholine. All normal subjects were non-responders, while all of the bronchial asthma cases, 63% of the chronic bronchitis cases and 50% of the acute bronchitis cases were responders. Among responders we found a very poor correlation between the initial respiratory conductance (Grs.cont) and the bronchial sensitivity (defined as the reverse of the cumulative dose until Rrs starts to increase); yet we found a good correlation between Grs.cont and the bronchial reactivity (defined as the slope of the decreasing rate of Grs). Metaproterenol and atropine decreased the bronchial sensitivity and reactivity in 28 asthmatic patients. We concluded that for clinical purposes the new method was very useful for assessing bronchial responsiveness to inhalation challenge because of its simplicity of operation as well as the quantitative differentiation between bronchial sensitivity and reactivity. Our results suggest that the bronchial response system to methacholine is explainable by a model of multiple dose-response curves without any parallel shift.View full abstractDownload PDF (2268K) -
Diminution of Bile Flow and of Liver Uptake and Biliary Excretion of Bromsulphthalein by AldosteroneFAYED AFIFI1981 Volume 135 Issue 2 Pages 139-147
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAFIFI, F. Diminution of Bile Flow and of Liver Uptake and Biliary Excretion of Bromsulphthalein by Aldosterone. Tohoku J. exp. Med., 1981, 135 (2), 139-147-In adult albino rabbits, aldosterone infusion in doses between 0.0217 and 11.00μg/kg b.wt/min resulted in a rapid diminution of£ bile flow (p<0.01). The biliary excretion of sodium and water was decreased. The liver uptake, the biliary excretion and the choleretic response to cholic acid were diminished in animals infused with aldosterone. The intravenous injection of 15mg/kg b. wt of bromsulphthalein, in rabbits infused with aldosterone produced a diminution of plasma clearance and biliary excretion of the dye (p<0.01).View full abstractDownload PDF (808K) -
HIROKI WATANABE, KIKUO AKIYAMA, TAKESI SAITO, FUMIYA OKI1981 Volume 135 Issue 2 Pages 149-154
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWATANABE, H., AKIYAMA, K., SAITO, T. and OKI, F. A Finite Deformation Theory of the Urinary Bladder. Tohoku J. exp. Med., 1981, 135 (2), 149-154-In the previous work, A Finite Deformation Theory of Intravesical Pressure and Mural Stress of the Urinary Bladder, we adopted the functional form of the strain-energy density W proposed by Valanis and Landel. In the present paper, the density W of the bladder is expressed as a function of the three principal invariants of the strain tensors. The reason why we adopted these variables is that in the molecular theory of rubber elasticity the W is known to be a simple function of those invariants, and we regarded the urinary bladder as an incompressible isotropic material like a rubber. The result is, however, the same as the previous one. It is also pointed out that the famous Moony-Rivlin plot is not applicable to the bladder.View full abstractDownload PDF (454K) -
KAORU SAGISAKA, MINEO IWASA, TSUYOSHI YOKOI, KAZUO KANEMITSU1981 Volume 135 Issue 2 Pages 155-163
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAGISAKA, K., IWASA, M., YOKOI, T. and KANEMITSU, K. The Specificity of Anti-A Agglutinins from Immunized Rabbits and Plant Lectins. Tohoku J. exp. Med., 1981, 135 (2), 155-163-A+ and A- rabbits were immunized with human A red cells, saliva of A+ or A- rabbits or human A.Se. A- rabbits responded well against A.Se saliva and A cells and slightly against A+ saliva, whereas A+ rabbits produced high-titered antibody against A cells which was abolished by absorption with O cells. Agglutination inhibition tests showed that anti-A from A- rabbits immunized with A.Se or A cells was not inhibited with A+ saliva, and anti-A from rabbits immunized with A cells was not absorbed with A.Se saliva. Hydroxylapatite chromatography separated each of A.Se and A+ saliva into three fractions of which the 1st and 3rd fractions of A.Se and only the 3rd of A+ had A activity. The 3rd fraction of A.Se and A+ did not inhibit anti-A from any rabbits immunized but the 1st of A.Se inhibited anti-A from all rabbits except for A+ immunized with A cells. The 1st and 2nd fractions reacted slightly with anti-A from A- immunized with A+ and from A+ immunized with A cells. D. biflorus anti-A distinguished human A from rabbit one but Mushroom anti-A could not. These results suggested qualitative differences between human and rabbit saliva A antigens.View full abstractDownload PDF (742K) -
KAZUYUKI AMANO1981 Volume 135 Issue 2 Pages 165-178
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAMANO, K. Numerical Variation of Parietal Cells after Vagotomy in Cases of Duodenal Ulcer. Tohoku J. exp. Med., 1981, 135 (2), 165-178-The present study was conducted histologically to elucidate the influence of vagotomy on the gastric mucosa. Bioptical tissues were obtained from 10 control cases and from 26 cases of duodenal ulcer using an endoscope. Of the 26 cases of duodenal ulcer, 20 were subjected to truncal vagotomy with pyloroplasty and 6 to truncal vagotomy with hemigastrectomy. In the cases of duodenal ulcer, tissues were obtained at the preoperative stage, and at 1, 3, 6 and 12 months on the time-course basis after the operation. The parietal cells were counted in a unit area (0.0176 mm2) between the middle and lower 1/3 part of the fundic gland in H.-E, stained paraffin sections under microscopy. The length of the fundic gland was also measured. The results are summarized as follows: (1) There were a greater number of parietal cells and the length of the fundic gland was longer in the preoperative cases than in the controls. (2) Postoperative observations revealed that the number of parietal cells and the length of the fundic gland significantly decreased up to 3 months after the operation by both surgical techniques. Thereafter, the number of parietal cells and the length of the fundic gland significantly increased in the cases subjected to vagotomy with pyloroplasty. (3) The difference between the two surgical techniques was made clear when the mean values for the absolute number of parietal cells were compared at 3 months after the operation, the absolute number of parietal cells being smaller in hemigastrectomy than in pyloroplasty.View full abstractDownload PDF (2014K) -
KOTARO YAMAMURA, NAOKI MAEHARA, IZUMI HARABUCHI, TERUKAZU SADAMOTO, KI ...1981 Volume 135 Issue 2 Pages 179-186
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMAMURA, K., MAEHARA, N., HARABUCHI, I., SADAMOTO, T., TAKAHASHI, K. and HAYAFUJI, C. The Effects of Intermittent (Trapezoidal) Noise on Man. Tohoku J. exp. Med., 1981, 135 (2) 179-186-Eight healthy students were exposed to intermittent noise to evaluate the effects of traffic noise on man. The experimental noise exposure conditions were as follows: Exp. 1: Control. Exp. 2: Peak level, 80 dB(A); rise-decay time, 1sec; duration, 3sec; and duty cycle 8sec (on fraction 25%). Exp. 3: Peak level, 75 dB (A); rise-decay time, 500msec; duration, 4.5sec; and duty cycle, 8sec (on fraction 50%). In all experiments, the exposure time was 14hr. Temporary threshold shift (TTS) growth was followed for 14hr while saliva cortisol levels were measured for a 24-hr period. Although the coefficient of the regression line of TTS growth recorded in Exp. 1 or Exp. 3 was not statistically significant, the value in Exp. 2 was statistically significant. The circadian rhythm pattern of the saliva cortisol level (during a 24-hr period, mean of 8 examinees) was observed in the three experiments. Essentially, the early morning level of saliva cortisol was high, while the daytime level was relatively low.View full abstractDownload PDF (779K) -
NOBORU YAMANAKA, YOSHIFUMI ISHII, HIROFUMI KOSHIBA, KOKICHI KIKUCHI1981 Volume 135 Issue 2 Pages 187-196
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMANAKA, N., ISHII, Y., KOSHIBA, H. and KIKUCHI, K. Immunohistological Detection of B Lymphocytes in the Rat Lymphoid Organs by Using Anti-Rat B Lymphocytes Serum. Tohoku J. exp. Med., 1981, 135 (2), 187-196-Anti-rat B lymphocyte serum (ARBS) was prepared by immunizing rabbits with purified B cells from rat spleen and by absorbing the rabbit serum with rat red blood cells and syngeneic sarcoma cells. The specificity of ARBS for rat B cells was confirmed by various cytologic and immunofluorescence studies. By indirect immunofluorescence on tissue sections of rat spleen and lymph nodes, anatomical localizations of B cells in lymphoid organs were lymphoid follicles of the lymph node and lymphocyte corona surrounding periarteriolar lymphoid sheaths of the spleen; while cells located in the thymus-dependent area were essentially devoid of immunofluorescence or no cytoplasmic immunofluorescence was observed in plasma cells. Thus, the B cell distribution in tissue sections was clearly demonstrated with ARBS. When the cross-reactivity of ARBS with mouse B cells was studied by complement-dependent cytotoxicity and immunofluorescence, it was found that mouse B cells shared at least one determinant of rat B lymphocyte specific antigens (RBLA) with rat B cells, and that the distribution pattern of the cross-reacting antigens in mouse lymphoid tissues was essentially the same as that of RBLA in rat lymphoid organs.View full abstractDownload PDF (1324K) -
KAORU SAGISAKA, HIROKO YAMASHITA, MIENO IWASA, TSUYOSHI YOKOI1981 Volume 135 Issue 2 Pages 197-204
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAGISAKA, K., YAMASHITA, H., IWASA, M. and YOKOI, T. Human Specific Antigens and Species Difference in Non-Hemoglobin Proteins of Red Cell Lysate. Tohoku J. exp. Med., 1981, 135 (2), 197-204- Non-hemoglobin proteins (NHPs) of 12 species of mammalian were effectively isolated from red cell lysates with CM-Sephadex chromatography. Polyacrylamide gel disc electrophoresis demonstrated that human and monkey NHPs had 13 and 11 bands, respectively, but guinea pig and swine two to three bands. Rabbit anti-human NHP reacted with monkey, bovine, canine and badger as well as human. Absorption of the anti-NHP with monkey NHP resulted in preparing human specific anti-NHP. The specific antiserum gave two bands locating near the origin in immunoelectrophoresis. Human specific antigens were prepared by affinity chromatography with the anti-NHP. The antigens were composed of three bands, two of which had slightly faster mobility than carbonic anhydrase and the other migrated fastly on disc electrophoresis. These bands were proved to have neither LDH nor esterase activity.View full abstractDownload PDF (2237K) -
MASAO ABE, ALEX SEVANIAN1981 Volume 135 Issue 2 Pages 205-211
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSABE, M. and SEVANIAN, A. The Effect of Oxygen Exposure on Erythrocyte Phospholipid Composition. Tohoku J, exp. Med., 1981, 135 (2), 205-211-Phospholipids in plasma and erythrocytes of rats exposed to 100% oxygen for 3 days were analyzed. Exposed rats contained lower quantities of several phospholipids in both plasma and erythrocytes than in matched controls. Pronounced decreases were found in phosphatidylcholine and lysophosphatidylcholine. The proportion of disaturated species in erythrocyte phosphatidylcholine was significantly greater after oxygen exposure. There was an increase in percentage of saturated fatty acids with a proportionate decrease in percentage of unsaturated fatty acids. The increase in saturation was associated primarily with palmitate while decreased unsaturation involved primarily linoleic acid. In plasma the proportions of stearic acid increased while those of linoleic, arachidonic and docosahexaenoic acids decreased in phosphatidylcholine. Damage to cell lipids may account for increased hemolysis which occurs after exposure to high oxygen concentrations. Erythrocytes recovered following oxygen exposure contained phospholipid species commonly found in immature red blood cells.View full abstractDownload PDF (751K) -
FUMIO TANAKA, KAZUHIKO FUKUDA, ATSUSHI ISHII1981 Volume 135 Issue 2 Pages 213-214
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTANAKA, F., FUKUDA, K. and ISHII, A. Cranial Computerized Tomography in a Patient with Wilson's Disease. Tohoku J. exp. Med., 1981, 135 (2), 213-214 -A 24-year-old female with Wilson's disease showed symmetrical low density zones on the cranial CT, which seemed to represent structural changes in the lentiform nuclei. Diagnostic and prognostic usefulness of CT in Wilson's disease was discussed.View full abstractDownload PDF (309K) -
SHINICHI OKUYAMA, HITOSHI MISHINA1981 Volume 135 Issue 2 Pages 215-216
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S. and MISHINA, H. Probable Superoxide Therapy of Experimental Cancer with D-Penicillamine. Tohoku J. exp. Med., 1981, 135 (2), 215-216-A sublethal dose of D-penicillamine (DP) induced hyperlipoperoxidemia and hypocupremia in old rats. Treatment of cancer cells in vitro and in vivo with DP resulted in appreciable suppression of cell multiplication and a remarkable inhibition of tumor growth. Erythropoiesis did not seem to be affected by DP. The selective effect of DP seems to have resulted from the reduced superoxide dismutase activity and/or defective Mn superoxide dismutase.View full abstractDownload PDF (193K) -
KENJI MIZUNO, MITSUHIRO GOTOH, SOITSU FUKUCHI1981 Volume 135 Issue 2 Pages 217-218
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIZUNO, K., GOTOH, M. and FUKUZHI, S. Effect of Sodium Intake on Brain Angiotensin-Converting Enzyme Activity in Spontaneously Hypertensive Rat. Tohoku J. exp. Med., 1981, 135 (2), 217-218-The effect of sodium intake on angiotensin-converting enzyme activity in five areas of the brain (the cerebral cortex, midbrain, striatum, thalamus and hypothalamus) was studied in normotensive, spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. The enzyme activity was significantly higher in the hypothalamus than in other areas of the brain of spontaneously hypertensive rats. Sodium intake resulted in a significant rise of the enzyme activity in the midbrain of spontaneously hypertensive rats and also in the midbrain and the striatum of stroke-prone spontaneously hypertensive rats. In normotensive rats, however, there was no significant difference in the enzyme activity in any area of brain between the control and the salt-treated group. It is likely therefore that a high circulating sodium level increases angiotensin-converting enzyme content of the brain in spontaneously hypertensive rats, and it is suggested that the increased converting-enzyme activity may play a role in development of hypertension induced by sodium loading.View full abstractDownload PDF (244K)
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