Effect of Tocopherol Deficiency on Lipid Metabolism in Arterial Wall of Spontaneously Hypertensive Rats on Normal and High Cholesterol Diets

Abstract

MURANO, S., SHIRAI, K., MATSUOKA, N., MORISAKI, N., SASAKI, N., SHINOMIYA, M., MIZOBUCHI, M., SAITO, Y. and KUMAGAI, A. Effect of Tocopherol Deficiency on Lipid Metabolism in Arterial Wall of Spontaneously Hypertensive Rats on Normal and High Cholesterol Diets. Tohoku J. exp. Med., 1982, 136 (1), 29-34 Lipid metabolism in the arterial wall of spontaneously hypertensive rats (SHR) fed on tocopherol-deficient diet, high-cholesterol diet or both was studied. Serum tocopherol was greatly decreased in tocopherol-deficient SHR. Lipoperoxide, determined as thiobarbituric acid-reactive substances, was higher in tocopherol-deficient SHR than in normal SHR. Tocopherol-deficient SHR showed a decrease in acid cholesterol esterase activity, but no change in neutral cholesterol esterase, acid and neutral lipase, acyl CoA synthetase, cytidine-diphosphate choline-1-2-diacyl glycerol choline phosphotransferase (CPT) or triglyceride synthesizing activity.