Abstract
WATANABA, H., KAWAI, K, and CHIBA, S. Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine. Tohoku J. exp. Med., 1982, 136 (1), 75-78 The effects of acetylcholine on the frequency-force relationship in isolated dog atria were investigated in a frequency range of 2-3.5Hz. The atria were suspended in a bath and perfused with arterial blood from a carotid artery of a heparinized donor dog. The frequency-force relationship was uniformly and dose-dependently suppressed by infusion of acetylcholin in 3 different doses at the frequency range of 2-3.5Hz, and acetylcholine did not induce a negative staircase.
