The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine
HIDEHIKO WATANABE, KIMIKO KAWAI, SHIGETOSHI CHIBA
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Keywords: isolated dog atria, frequency-force relationship, acetylcholine
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1982 Volume 136 Issue 1 Pages 75-78

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Abstract

WATANABA, H., KAWAI, K, and CHIBA, S. Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine. Tohoku J. exp. Med., 1982, 136 (1), 75-78 The effects of acetylcholine on the frequency-force relationship in isolated dog atria were investigated in a frequency range of 2-3.5Hz. The atria were suspended in a bath and perfused with arterial blood from a carotid artery of a heparinized donor dog. The frequency-force relationship was uniformly and dose-dependently suppressed by infusion of acetylcholin in 3 different doses at the frequency range of 2-3.5Hz, and acetylcholine did not induce a negative staircase.

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