The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine
HIDEHIKO WATANABE, KIMIKO KAWAI, SHIGETOSHI CHIBA
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キーワード: isolated dog atria, frequency-force relationship, acetylcholine
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1982 年 136 巻 1 号 p. 75-78

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WATANABA, H., KAWAI, K, and CHIBA, S. Frequency-Force Relationship in Dog Atrial Muscle as Modified by Acetylcholine. Tohoku J. exp. Med., 1982, 136 (1), 75-78 The effects of acetylcholine on the frequency-force relationship in isolated dog atria were investigated in a frequency range of 2-3.5Hz. The atria were suspended in a bath and perfused with arterial blood from a carotid artery of a heparinized donor dog. The frequency-force relationship was uniformly and dose-dependently suppressed by infusion of acetylcholin in 3 different doses at the frequency range of 2-3.5Hz, and acetylcholine did not induce a negative staircase.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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