The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
Increased Frequency of Lymphocytotoxic Antibodies in Patients with Multiple Sclerosis Correlated with Disease Activity
Author information

Volume 136 (1982) Issue 2 Pages 121-128

Download PDF (748K) Contact us

TSUKAMOTO, T., EBINA, T., TAKASE, S., ITAHARA, K. and ISHIDA, N. Increased Frequency of Lymphocytotoxic Antibodies in Patients with Multiple Sclerosis Correlated with Disease Activity. Tohoku J. exp. Med., 1982, 136 (2), 121-128-Cold-reactive lymphocytotoxic antibodies (LCA) were investigated in sera from patients with multiple sclerosis (MS) in relation to disease activity. When a serum with more than 20% cytotoxicity is considered positive for the presence of LCA, the positive frequency at remission was 21% (6/28), but at exacerbation it was 83% (10/12). All the sera from normal controls were negative. The average of cytotoxicity expressed as a % killing of target cells by sera at remission was 13%; on the other hand, at exacerbation it was 39%. These results showed that in multiple sclerosis the level of LCA was not persistently high, but increased correlating with the disease activity. From these findings and previous experiments of rescue of measles virus antigens, it was suggested that multiple sclerosis is likely a virus-induced autoimmune disease.

Information related to the author
© Tohoku University Medical Press
Previous article Next article

Recently visited articles
  • About this Journal
    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.

  • Submitted manuscripts will be screened for plagiarism with Similarity Check (
Journal news & Announcements
  • Subscriptions
    Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN.

    Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN.