1982 年 138 巻 1 号 p. 27-37
HASHIMOTO, Y., RIGOR, B.M. and MORENO, J.A. Cardiovascular Effects of Hypotension Induced by Adenosine Triphosphate and Sodium Nitroprusside on Dogs with Denervated Hearts. Tohoku J, exp. Med., 1982, 138 (1), 27-37 Adenosine triphosphate (ATP) and sodium nitroprusside (SNP) are administered to patients to induce and control hypotension during anesthesia. SNP is authorized for clinical use in USA and UK, and ATP is clinically used in other countries such as Japan. We investigated how these two drugs act on the cardiovascular systems of 20 dogs whose hearts had been denervated by a procedure we had devised. ATP (10 dogs) or SNP (10 dogs) was administered to reduce mean arterial pressure by 30% to 70% of control. Before, during and after induced hypotension, we measured major cardiovascular parameters. Hypotension induced by ATP was accompanied by significant decreases in mean pulmonary arterial pressure (p<0.001), central venous pressure (p<0.001), left ventricular end-diastolic pressure (p<0.001), total peripheral resistance (p<0.001), rate pressure product (p<0.001), total body oxygen consumption (p<0.05), and heart rate (p<0.001); all these variables returned normal within 30min after ATP was stopped. Cardiac output did not change. During hypotension produced by SNP similar decreases were observed in mean pulmonary arterial pressure (p<0.01), central venous pressure (p<0.001), left ventricular end-diastolic pressure (p<0.01), total peripheral resistance (p<0.001), rate pressure product (p<0.001), and oxygen content difference between arterial and mixed venous blood (p<0.05), while heart rate (p<0.001) and cardiac output (p<0.05) were increased. Recoveries of heart rate and left ventricular end-diastolic pressure were not shown within 60min after SNP had been stopped. Both ATP and SNP should act on the pacemaker tissue of the heart.
