Biphasic Change in Human Peripheral Vascular Resistance Produced by Carnigen^®

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IWATSUKI, N., AMAHA, K. and KOGA, Y. Biphasic Change in Human ® Peripheral Vascular Resistance Produced by Carnigen^®. Tohoku J. exp. Med., 1982, 138 (1), 81-85-The response of the human peripheral vascular resistance (TPR) to carnigen^® was examined on 11 patients by measuring arterial pressure change during cardiopulmonary bypass at a constant pump flow. The administration of 2ml of carnigen into the bypass for the adult and 1ml for the child produced an initial transient (36sec) decrease in arterial pressure (9%) followed by a definite increase (13% at 5min after administration). The present results, therefore, reveal that carnigen possesses a property changing human TPR in bphasic mode; a transient decrease at first followed by a definite increase.