Studies on the Detoxicating Hormone of the Liver (Yakriton)

16th Report. Prophylactic Effect of Yakriton against Ammonium Carbonate Convulsion

Abstract

Normal rabbits are liable to develop convulsions on the intraperitoneal administration of fresh 3.1% ammonium carbonate, though the reaction to the poison at each trial is not so regular as in the case of ammonium chloride. Besides they succumb more easily on account of fatal convulsion, which appears more similar to the urea convulsion⁵⁾ than to the ammoniac convulsion. Thus there can be no direct comparison of toxicity between the commercial ammonium carbonate and the ammonium chloride. If, however, the preventive efficacy of yakriton is taken into consideration, the former may be said to be roughly 3 times as toxic as the latter, because not 10 R. A. U. of yakriton, but 30 R. A. U., can prevent animals from injurious effects arising from intraperitoneal administration of ammonium carbonate.