The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
The Occurrence of Marker Cells in Fetal Hematopoiesis of Beige (Chédiak-Higashi) Mouse
MICHIO YATABE, WAKAKO TAKAHASHI, OTOTAKA HIGASHI
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Keywords: Chédiak-Higashi syndrome, beige mouse, fetal hematopoiesis, prenatal diagnosis, giant granules of neutrophils
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1983 Volume 140 Issue 3 Pages 331-334

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Abstract

YATABE, M., TAKAHASHI, W. and HIGASHI, O. The Occurrence of Marker Cells in Fetal Hematopoiesis of Beige (Chédiak-Higashi) Mouse. Tohoku J. exp. Med., 1983, 140 (3), 331-334-The presence of neutrophils and their precursors with peroxidase-positive and sudanophilic giant granules, which are characteristic of Chédiak-Higashi syndrome (CHS), in the fetal liver and blood of beige (CH), but not of the control C 57 Black, mice was observed. This finding supports the view that the prenatal diagnosis could be possible, if the fetal blood specimen is obtainable safely, assuming the occurrence of similar marker cells in fetal hematopoiesis in CHS of human.

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