The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Effect of Pantethine on Fatty Acid Oxidation in Microvessels of Rat Brain
NOBUHIRO MORISAKI, NOBUO MATSUOKA, KOHJI SHIRAI, NORIHIRO SASAKI, YASUSHI SAITO, AKIRA KUMAGAI
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キーワード: brain microvessels, fatty acid oxidation, angionecrosis, pantethine
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1983 年 141 巻 1 号 p. 41-45

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MORISAKI, N., MATSUOKA, N., SHIRAI, K., SASAKI, N., SAITO, Y. and KUMAGAI, A. Effect of Pantethine on Fatty Acid Oxidation in Microvessels of Rat Brain. Tohoku J. exp. Med., 1983, 141 (1), 41-45 - Fatty acid oxidation in brain microvessels decreased greatly when persistent hypertension developed in spontaneously hypertensive rats (SHR). Treatment of SHR with pantethine [D-bis-(N-pantothenyl-β-aminoethyl) disulfide] in vivo for 4 weeks restored their fatty acid oxidation activity to the control level. The mechanism of the activating effect of pantethine on fatty acid oxidation was investigated in brain microvessels. Pantethine and its metabolites (pantetheine and 4'-phosphopantetheine) activated three steps of fatty acid oxidation, i.e., acyl-CoA synthetase, carnitine acyltransferase and intramitochondrial oxidation. The relation between changes in fatty acid oxidation activities and injuries of brain microvessels and the protective effect of pantethine against such injuries is discussed.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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