Late Pulmonary Response in Guinea Pigs after Ascaris Challenge

Abstract

TAKISHIMA, T., YAMAUCHI, K., ISHII, M., CHAO, C.-L., IIJIMA, H., SHIMURA, S., SHINDOH, Y., INOUE, H. and MUE, S. Late Pulmonary Response in Guinea Pigs after Ascaris Challenge. Tohoku J. exp. Med., 1985, 146 (1), 121-122-Respiratory resistance of guinea pigs immunized with Ascaris suum was measured over 6hr after aerosol challenge of the allergen by use of the oscillation method. These animals showed a biphasic pulmonary response to the aerosol challenge with Ascaris suum. Histological analysis of these animals revealed a narrowing of bronchial lumen, peribronchial edema and neutrophil-rich mucous in bronchial lumen at the late pulmonary response.