Abstract
YAMAMOTO, M., SAKURADA, T., YOSHIDA, K., KAISE, K., KAISE, N., FUKAZAWA, H., SUZUKI, M., NOMURA, T., ITAGAKI, Y., SAITO, S. and YOSHINAGA, K. Effect of Carteolol, Indenolol and Metoprolol on the Thyroid Hormone of Hyperthyroid Patients. Tohoku J. exp. Med., 1985, 146(4), 385-390-Thirty - four hyperthyroid patients were divided into four groups: placebo, carteolol (20mg/day), indenolol (60mg/day) and metoprolol (120mg/day) groups. The heart rate was determined before and two weeks after the treatment with each drug. Serum levels of T4, T3 and rT3 were measured before, and one and two weeks after the treatment. Both indenolol and metoprolol significantly reduced the heart rate (p<0.01 and p<0.05, respectively), whereas carteolol was ineffective. Carteolol significantly decreased T4 from 23.4±4.4μg/100ml to 20.1±3.2μg/100ml (p< 0.01) in one week and to 20.0±3.7μg/100ml (p<0.01) in two weeks. T3 and rT3 were also decreased significantly (p<0.05 and p<0.01, respectively) two weeks after the treatment with carteolol. After two weeks of indenolol treatment, T4 was decreased significantly from 26.2±8.5μg/100ml to 23.9±8.2μg/100ml (p< 0.05) and T3 from 789±391ng/100ml to 592±340ng/100 ml (p<0.02). Metoprolol had no effect on serum thyroid hormone levels. The decrease in the serum level of thyroid hormones by carteolol and indenolol but not by metoprolol in patients with hyperthyroidism would be due to the blockade of β2-adrenoreceptors concerning with thyroid hormone secretion.
