Abstract
UCHIDA, T., MUROI, S., YUI, T., HIRAGURI, M., YANAGISAWA, S., UMEZU, H. and KARIYONE, S. Influence of Viramin E on Platelet Survival. Tohoku J. exp. Med., 1985, 147 (4), 343-348-Vitamin E plays an important role in protecting fat tissue from peroxidation. Platelet survival was compared among vitamin E deficient, control and α-tocopheryl nicotinate supplemented rats. The mean tocopherol level in the sera of the rats fed vitamin E deficient diet for two months was 21.5% of control, and the lipoperoxide level in the sera of these animals had not significantly (p>0.05) increased. Platelet aggregation was not accelerated significantly (p>0.05) after exposure to a concentration of 10μM of ADP used as an aggregating agent. The rate of platelet survival was determined by the 51Cr-labeling technique. The survival rates were all normal in vitamin E deficient, control and α-tocopheryl nicotinate supplemented rats, with no significant difference (p>0.1) among the groups. These results suggest that depletion of vitamine E per se does not shorten the periods of platelet survival.
