Estimation of a Drug Effect by a Simplified Radioaerosol Inhalation Lung Cine-Scintigraphy: Bromhexine on Mucociliary Clearance Mechanisms

Abstract

ISAWA, T., TESHIMA, T., HIRANO, T., EBINA, A. and KONNO, K. Estimation of a Drug Effect by a Simplified Radioaerosol Inhalation Lung Cine-Scintigraphy: Bromhexine on Mucociliary Clearance Mechanisms. Tohoku J. exp. Med., 1986, 148 (2), 163-167 - A proposed simplification of radioaerosol inhalation lung cine-scintigraphy, namely 60min measurement of radioactivity without repeating measurement at 24hr later and calculation of alveolar deposition ratio (ALDR) by the regression formula of ALDR=-48.08+0.47×FEV1.0%+0.59×LRR60, was found useful and applicable even to the evaluation of a drug on mucociliary clearance mechanisms. The simplified method indicated a very similar evaluation of the effect of bromhexine on airway clearance efficiency with those actually revealed by the original method.