Abstract
KUMANO, N., KOINUMARU, S., DIZUMI, K. and KONNO, K. cis-Diamminedichloroplatinum (CDDP)-Fosfomycin (FOM) Combination in Lung Cancer Patients with Respect to the Peripheral T Lymphocyte Subsets. Tohoku J. exp. Med., 1986, 148 (3), 333-334 - An antibiotic FOM was found to be preventive of the side effect of an antineoplastic drug CDDP on the peripheral T lymphocytes in lung cancer patients. Whereas finding a significant decrease in T3+ cells (p<0.01) and T4+ subset (p<0.05) with CDDP alone, the initial levels of these cell populations were kept unchanged in combination with FOM. T8+ subset showed no substantial change. A protective effect of FOM on T4+ subset was suggested to be an additional aspect of its action at least in combination with CDDP.
