1986 Volume 150 Issue 2 Pages 225-226
TANAKA, M., NISHIZAWA, M., INUZUKA, T., BABA, H., SATO, S., MIYATAKE, T., AOKI, S. and SHINADA, S. Chronic T Cell Leukemia with a NK Phenotype Reacting with Anti-Myelin-Associated Glycoprotein (MAG) Mouse Monoclonal Antibody. Tohoku J. exp. Med., 1986, 150 (2), 225-226-We describe a patient demonstrating chronic T cell leukemia with a natural killer (NK) phenotype. The leukemic cells could be stained by OKT 3 (T cells), anti-Leu-7 and anti-myelinassociated glycoprotein (MAG) (NK cells) but not anti-Leu-11 monoclonal mouse antibody (activated NK cells). Fresh mononuclear cells showed a very low NK activity, although this activity returned to normal levels after 18 days incubation with interleukin-2 and some stimulants. It was not known why the NK activity of fresh mononuclear cells was low. This report is the first on leukemia characterized by anti-MAG monoclonal antibody.
