抄録
ITO, K., MIYAKAWA, H. and KATO, H. The Long-Term Facilitation of Neuronal Activity Produced by Repeated Pairing of an Orthodromic Stimulus and Antidromic Stimuli in the Sliced Hippocampal Formation. Tohoku J. exp. Med., 1986, 150 (2), 229-230-Long-term facilitation in extracellulary recorded population spikes was demonstrated by repeated paired stimulation (RPS) in CAl neurons of the guinea pig hippocampal slices. Paired stimulation, consisting of a single orthodromic “test” stimulus and a train (5 pulses at 200Hz) of antidromic stimuli with an interstimulus interval (ISI) of 20, 500msec or 1sec was repeated every 5sec over a 250sec period. The amplitude of the population spike in response to the test stimulus increased gradually after RPS and reached a plateau level 30-50min after RPS. The plateau value was dependent on ISI; the shorter the ISI the greater the increase of responses. In contrast, no facilitation was observed when either the test stimulus or the antidromic stimuli were applied separately, without pairing.
