Abstract
OKUYAMA, S., MISHINA, H., YOSHIZUMI, A., USUBA, Y. and TAKAHASHI, M. Intratumoral Doxycycline for Skin Metastases of Human Malignancies. Tohoku J. exp. Med., 1987, 151(2), 241-244-As soon as its inducibility of lethality via prompt deprivation of heavy metals and HDL-cholesterol was born out, an intratumoral administration of doxycycline, an anti-prokaryotic agent, was undertaken in 7 patients presenting with skin metastases from a variety of malignancies. Complete remission of these lesions was attained in 6. The histological observation of elongated areas of acellularity along with central vessels appeared to suggest doxycycline-mediated cellular disintegration, resulting in empty tumor cords. Specific tumor selectivity of the treatment can be sustained by the intra-and/or peri-tumoral confinement of the agent. The technique may constitute a novel mode of cancer cell elimination.
