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Volume 151 (1987)
- Issue 4 Pages 363-
- Issue 3 Pages 253-
- Issue 2 Pages 129-
- Issue 1 Pages 1-
Volume 151, Issue 2
Displaying 1-14 of 14 articles from this issue
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YUTAKA MIZUSHIMA, HIROTOKU NAGAHAMA, AKIHITO YOKOYAMA, TOSHIHIKO MORIK ...1987 Volume 151 Issue 2 Pages 129-135
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIZUSHIMA, Y., NAGAHAMA, H., YOKOYAMA, A., MORIKAGE, T. and YANO, S. Studies on Nephrotoxicity Following a Single and Repeated Administration of cis-Diamminedichloroplatinum (CDDP) in Rats. Tohoku J. exp. Med., 1987, 151 (2), 129-135-Nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) was investigated in male Wistar rats. When CDDP in a single dose of 4mg/kg was injected i.p, into animals, serum creatinine (Cr) and blood urea nitrogen (BUN) reached a peak after 4 days and returned to the initial levels within two weeks. Nephrotoxicity of CDDP was dose-dependent, and related to the route of administration in the following order of i.p.s.c.i.v. When CDDP (4mg/kg) was injected i.p. repeatedly at intervals of three weeks, a decrease in nephrotoxicity was observed after the 2nd injection of drug. This decreased nephrotoxicity was detected as early as a week after the 1st injection. Following the 3rd injection, nephrotoxicity showed an accumulative pattern. The change in the route of administration or its regimen did not alter the pattern of CDDP-induced nephrotoxicity. Decreased nephrotoxicity after the 2nd injection of the drug seems to be interesting from viewpoint of a host defense response.View full abstractDownload PDF (554K) -
ICHIRO TSUJI, RYUICHI NAKAMURA1987 Volume 151 Issue 2 Pages 137-143
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTSUJI, I. and NAKAMURA, R. The Altered Time Course of Tension Development during the Initiation of Fast Movement in Hemiplegic Patients. Tohoku J. exp. Med., 1987, 151(2), 137-143-The time course of tension development produced by fast isometric contraction of the quadriceps femoris muscle for knee extension was examined on eight normal subjects and 14 patients with spastic hemiparesis due to stroke. Tension lag time (TLT), the latency from the onset of EMG activities to the rise of tension, and contraction time (FTmax), the period from the rise of tension to its maximum, were longer in the patients than in the normal subjects. The prolongation of FTmax correlated with the decreased rate of tension development. The results indicated that the temporal characteristics of tension development altered in the spastic paresis, reflecting functional changes in the muscle and motor neurons.View full abstractDownload PDF (658K) -
II. Control of Acid-Base Balance with AcetazolamideKENJI TAKI, NOBUAKI TAKAHASHI, KEISHI MIZUNO, REIJI WAKUSAWA1987 Volume 151 Issue 2 Pages 145-154
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKI, K., TAKAHASHI, N., MIZUNO, K. and WAKUSAWA, R. Management of Acid-Base Balance with Red Blood Cell Carbonic Anhydrase (RCA). II. Control of Acid-Base Balance with Acetazolamide. Tohoku J. exp. Med., 1987, 151(2), 145-154-Acetazolamide, a carbonic anhydrase (CA) inhibitor, was used to normalize metabolic alkalemia. A dosage of acetazolamide for normalizing metabolic alkalemia has not yet been experimentally determined. The dosage of acetazolamide for this purpose is experimentally calculated in this paper. The correlation between various concentrations of acetazolamide mixed with blood and the base excess (BE) levels in blood at the start of normalizing metabolic alkalosis was studied in vitro. The change rate of the BE level was calculated from BE levels noted before and after tonometry of the blood with and without acetazolamide. A dosage of acetazolamide which can cause the change rate of the BE level to decrease is considered to be an effective dosage. Metabolic alkalosis in vitro was produced by adding bicarbonate into the blood. An effective dosage of acetazolamide for metabolic alkalemia of which the BE range was from 0 to +30 mEq/liter was calculated. CA activities in the kidney and the blood of dogs administered acetazolamide were examined. The effective dosage of acetazolamide obtained from in vitro experiments inhibited the CA activities not only in the blood but also in the kidneys. An effective dosage of acetazolamide to normalize a BE of +10mEq/liter in vitro was converted into about 7-12mg/kg in vivo. This dosage inhibited the red blood cell carbonic anhydrase (RCA) activity to 20-40%, whereas the normal physiological variation range is 25%. An effective dosage of acetazolamide in the blood did not proportionally increase with an increase of HCO3- during severe alkalosis. It might be suggested that a small dose (1-2mg/kg) of acetazolamide sufficiently normalized severe alkalemia (BE+30mEq/liter) in a patient.View full abstractDownload PDF (911K) -
MIKIO IMAMURA, MORIHIKO TODA, YOSHIROO SUZUKI, IWAO SASAKI, TOSHIO SAT ...1987 Volume 151 Issue 2 Pages 155-168
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIMAMURA, M., TODA, M., SUZUKI, Y., SASAKI, I., SATO, T. and OHNEDA, A. The Role of Humoral Factors and the Ileocecal Valve in Pathological Changes Occurring after Distal Small Bowel Resection. Tohoku J. exp. Med., 1987, 151(2), 155-168-Experimental studies using dogs were performed to elucidate the participation of gastrointestinal hormones as well as the ileocecal valve in postoperative sequelae following massive small bowel resection. Although in both the ileal resection and the ileocecal resection groups the absorption of fat was reduced postoperatively, body weight tended to increase in the former, while it decreased gradually in the latter. In addition, watery diarrhea persisted after ileocecal resection. Plasma total bile acid concentrations in each group were lower than those before surgery, as were plasma levels of both total glucagon and neurotensin. Although differences were not significant, plasma neurotensin levels tended to be higher after ileocecal resection, but plasma total glucagon levels tended to be lower. Plasma gastric inhibitory polypeptide (GIP) response to butter ingestion was also lower after both ileal and ileocecal resection; especially in the latter case the decrease was significant. These results indicate that the diminished plasma levels of neurotensin, enteroglucagon and GIP may be related to the impairment of adaptive changes in the remaining small intestine.View full abstractDownload PDF (1435K) -
TOMOKO ITO, TOM MORI1987 Volume 151 Issue 2 Pages 169-180
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSITO, T. and MORI, T. Peridermal Granules of the Chick Embryo: Histochemical, Ultrastructural and Immuno-Electron Miroscopical Study. Tohoku J. exp. Med., 1987, 151(2), 169-180-In the chick embryo, the periderm covering certain derivatives of the integumentum, such as the beak, the scale and the claw, grows thick and contains specific cytoplasmic granules. In this report, we present the histochemical properties and the fine structures of these peridermal granules especially over the egg tooth region of the upper beak. The granules were brilliantly stained with acid dyes. A positive reaction for tyrosine and arginine suggested that this acidophilia was due to a certain basic protein. Although the reaction of DDD to SH and SS groups was moderate, a presence of keratin was strongly suggested immunohistochemically by using the rabbit anti-keratin antiserum. There also existed a possibility of some compound lipids. Under an electron microscope, these granules were found to consist of anastomosing ribbons which were less than 60nm in width and were stained with rabbit anti-keratin antiserum.View full abstractDownload PDF (7162K) -
YOSHINORI OHTSUKA, TAKAHITO KONDO, MICHIRO SHIMADA, KAZUHIRO MURAKAMI, ...1987 Volume 151 Issue 2 Pages 181-190
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHTSUKA Y., KONDO, T., SHIMADA, M., MURAKAMI, K., IDE, H. and KAWAKAMI, Y. Erythrocyte Insulin Receptor in Insulin Autoimmune Syndrome: Effects of Corticosteroid Therapy. Tohoku J. exp. Med., 1987, 151(2), 181-190 -Changes in the erythrocyte insulin receptors were studied in a patient with insulin autoimmune syndrome before and after corticosteroid therapy. In this case, despite a quite low fasting plasma glucose value (29mg/100ml), a 75g oral glucose tolerance test (OGTT) showed a diabetic curve and extremely high immunoreactive insulin (IRI) levels were observed. After 6 months duration of the disease, corticosteroid was given to the patient and hypoglycemic attacks disappeared with an improvement of the levels of plasma glucose. The number of insulin receptors decreased from 58 to 29 sites/erythrocyte and an increase in binding affinity or maximal binding ability were observed after the treatment with corticosteroid. These receptor changes, for the most part, might be derived from the steroid effects, since there were similar results when we administered steroid for a long term to a certain disease. There was a 20% reduction in the amount of insulin binding IgG purified from the serum one month after treatment with corticosteroid as compared with that purified from the serum before the treatment. The results suggest the usefulness of corticosteroid therapy in treatment of the insulin autoimmune syndrome.View full abstractDownload PDF (916K) -
NARIHIDE GOSEKI, TOKIO ONODERA, MORIO KOIKE, GORO KOSAKI1987 Volume 151 Issue 2 Pages 191-200
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSGOSEKI, N., ONODERA, T., KOIKE, M. and KOSAKI, G. Inhibitory Effect of L-Methionine-Deprived Amino Acid Imbalance Using Total Parenteral Nutrition on Growth of Ascites Hepatoma in Rats. Tohoku J. exp. Med., 1987, 151 (2), 191-200-The antitumor effect of an amino acid imbalance characterized by the absence of L-methionine was investigated in AH-109A ascites hepatoma-bearing rats with the technique of total parenteral nutrition (TPN). A central venous catheter was placed at the superior vena cava of the rat and hypertonic glucose solution plus an amino acid mixture, an ordinary amino acid compound but lacking L-methionine and L-cysteine, was administered as protein source for seven days. Increases in the volume of ascites and the number of tumor cells were significantly inhibited in the rats receiving glucose plus L-methionine-free amino acid mixture compared to the control rats given glucose only, glucose plus ordinary amino acid mixture and laboratory rations. Unfavorable side effects of TPN with amino acid compound lacking L-methionine and L-cysteine were loss of body weight and development of hypoproteinemia. No evidence of hepatic injury and bone marrow suppression due to this treatment were obtained from the results of biochemical and hematological studies. In liver cells and ascites tumor cells, morphologically, prominent enlargement of the nucleoli was observed in the rats treated with the amino acid mixture lacking of L-methionine and L-cysteine.View full abstractDownload PDF (1439K) -
TAKASHI MORITA, SHUN KONDO, SHINOBU DOHKITA, SEIGI TSUCHIDA1987 Volume 151 Issue 2 Pages 201-204
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMORITA, T., KONDO, S., DOHKITA, S. and TSUCHIDA, S. The Time Course of Changes in Force and Cyclic AMP Levels Produced by Isoproterenol and Forskolin in Isolated Rabbit Detrusor Muscle. Tohoku J. exp. Med., 1987, 151(2), 201-204 -The effects of forskolin and isoproterenol on contractile force and cyclic AMP (cAMP) levels were compared in rabbit detrusor. Both forskolin and isoproterenol produced relaxation of rabbit detrusor and an increase in cAMP levels in the tissue. Although the relaxant response to forskolin was similar to that of isoproterenol, the increase in cAMP levels induced by forskolin was significantly larger than that induced by isoproterenol. These results suggest that there is a discrepancy in the relaxation responses and cAMP levels in response to forskolin and isoproterenol.View full abstractDownload PDF (359K) -
MASATSUGU MORIKAWA1987 Volume 151 Issue 2 Pages 205-212
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMORIKAWA, M. Ventricular Arrhythmias in the Long-Term Postoperative Stage of Tetralogy of Fallot. Tohoku J. exp. Med., 1987, 151(2), 205-212-Arrhythmias were studied in 40 patients in the long-term stage after corrective surgery of tetralogy of Fallot. Holter monitoring showed ventricular dysrhythmias in 30 cases. Lown's grade 3 was found in 9, 4a in 5, and 4b in 5 cases. Five patients had ventricular arrhythmias of Lown's 3 or higher grade both in the treadmill stress test and in the Holter ECG. Twenty patients with ventricular arrhythmias of Lown's grade 3 or higher ones were associated with severer hemodynamic, and clinical abnormalities than those with ventricular arrhythmias of lower grade. Supraventricular arrhythmias or bifascicular block are also found in the group with complex ventricular arrhythmias but no cardiac arrest from sinus standstill or complete heart block was observed. Both the age at operation and the years after the corrective surgery were related to the incidence of ventricular arrhythmias of higher grades. Two patients with nonsustained ventricular tachycardia died suddenly during 2 years' follow up period. Tachyarrhythmia seems a major cause of sudden death after repair of tetralogy of Fallot. An electrophysiologic study may be reasonably indicated to prevent sudden cardiac death.View full abstractDownload PDF (743K) -
NOBUYOSHI TAKAHASHI, YUKIHIRO KOIZUMI, TOSHIAKI KAWAGUCHI, KOHICHI TAK ...1987 Volume 151 Issue 2 Pages 213-220
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKAHASHI, N., KOIZUMI, Y., KAWAGUCHI, T., TAKAHASHI, K., SUZUKI, T. and FUNYU, T. Production of a Monoclonal Antibody Selective to Human Transitional Cell Carcinoma. Tohoku J. exp. Med., 1987, 151(2), 213-220-In order to detect the bladder tumor specific antigens, the monoclonal antibody (MoAb) No. 10 to human transitional cell carcinoma of the bladder (T.C.C.B.) was obtained. Hybridomas were prepared by cell fusion between the mouse myeloma cell line × 63 Ag 8.653 and the spleen cells of BALB/c mouse hyperimmune to the bladder cancer cells (grade 2) from a patient, and were cloned. Consequently 12 MoAb-producing clones were obtained for the panel screening by enzymeimmunoassay (EIA) and then 3 MoAbs (No. 10, 11 and 14) were selected for the testing of reactivity to bladder cancer cells from patients including normal epithelia. Finallly No. 10 was selected as the most appropriate MoAb for this study and was determined IgM with kappa-light chains by EIA.View full abstractDownload PDF (3388K) -
NOBORU NUSHIRO, KEISHI ABE, MASAHIDE SEINO, KEN OMATA, KAORU YOSHINAGA1987 Volume 151 Issue 2 Pages 221-231
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNUSHIRO, N., ABE, K., SEINO, M., OMATA, K. and YOSHINAGA, K. The Effects of Intravenous Injection of α-Human Atrial Natriuretic Polypeptide on Blood Pressure, Renal Hemodynamics and Urinary Kinin Excretion in Anesthetized Rabbits. Tohoku J. exp. Med., 1987, 151(2), 221-231-Studies were performed in anesthetized rabbits to examine the effects of α-human atrial natriuretic polypeptide (α-hANP) on blood pressure, renal hemodynamics and urinary kinin excretion. Intravenous bolus injection of α-hANP at a dose of 5μg resulted in a transient increase in renal blood flow from 26.6±2.2 to 33.7±2.2ml/min (p<0.05) and a decrease in mean arterial pressure from 113±1.8 to 107±2.2mmHg (p< 0.01). The calculated renal vascular resistance decreased from 4.50±0.34 to 3.28±0.20mmHg/ml/min (p<0.05). This vasodilatory effect of α-hANP was immediate and lasted for 30min. These hemodynamic alterations were not associated with the changes in glomerular filtration rate estimated by creatinine clearance. Intravenous injection of α-hANP also produced marked increases in urine volume from 1.99±0.43 to 5.7±1.20ml 10min (p<0.01), urinary sodium from 42.2±7.6 to 243±54μEq/10min (p<0.01), urinary potassium from 37.5± 5.5 to 74.8± 10.3μEq/10min (p<0.01), and urinary kinin excretion from 3.44± 0.49 to 5.26±0.82ng/10min (p<0.05). The observed natriuretic effect of α- hANP lasted only for 30min, whereas diuretic and kaliuretic effects were sustained for 120min. Hematocrit levels did not change significantly throughout the experiment. These results indicate that α-hANP is a potent vasodilator substance and that the natriuretic effect induced by the bolus injection of α-hANP is mediated mainly through its renal vasodilatory action. It is also suggested that the renalkinin, at least in part, contributes to the natriuretic effect of α-hANP.View full abstractDownload PDF (981K) -
HIROYUKI KATO, KAZUO KOBAYASHI, SHUZO KOHARI, NAOSHI OKITA, KUNIHIRO I ...1987 Volume 151 Issue 2 Pages 233-239
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKATO, H., KOBAYASHI, K., KOHARI, S., OKITA, N. and IIJIMA, K. Paroxysmal Kinesigenic Choreoathetosis and Paroxysmal Dystonic Choreoathetosis in a Patient with Familial Idiopathic Hypoparathyroidism. Tohoku J. exp. Med., 1987, 151 (2), 233-239-A patient with familial idiopathic hypoparathyroidism whose major symptoms were paroxysmal kinesigenic choreoathetosis (PKC) and paroxysmal dystonic choreoathetosis (PDC) was reported. CT revealed marked calcification in the basal ganglia, the thalamus and the dentate nucleus of cerebellum. Positron emission tomographic (PET) study showed decreased glucose metabolism in the basal ganglia and thalamus. The paroxysms were eliminated by the normalization of serum calcium level. Thus the paroxysms seemed to be induced by hypocalcemia which stimulated the lesions in the basal ganglia and thalamus, on one occasion, as in PKC, and on the other occasion, as in PDC. Concomitant occurrence of both PKC and PDC in a patient is unique and is of interest in considering the pathomechanisms of these different but related disorders.View full abstractDownload PDF (3583K) -
SHINICHI OKUYAMA, HITOSHI MISHINA, ATSUO YOSHIZUMI, YASUKO USUBA, MASA ...1987 Volume 151 Issue 2 Pages 241-244
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S., MISHINA, H., YOSHIZUMI, A., USUBA, Y. and TAKAHASHI, M. Intratumoral Doxycycline for Skin Metastases of Human Malignancies. Tohoku J. exp. Med., 1987, 151(2), 241-244-As soon as its inducibility of lethality via prompt deprivation of heavy metals and HDL-cholesterol was born out, an intratumoral administration of doxycycline, an anti-prokaryotic agent, was undertaken in 7 patients presenting with skin metastases from a variety of malignancies. Complete remission of these lesions was attained in 6. The histological observation of elongated areas of acellularity along with central vessels appeared to suggest doxycycline-mediated cellular disintegration, resulting in empty tumor cords. Specific tumor selectivity of the treatment can be sustained by the intra-and/or peri-tumoral confinement of the agent. The technique may constitute a novel mode of cancer cell elimination.View full abstractDownload PDF (2501K) -
TADASHI TERUI, HIDEAKI TAKEMATSU, TAIZO KATO, KYOKO OHKOHCHI, HACHIRO ...1987 Volume 151 Issue 2 Pages 245-252
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTERUI, T., TAKEMATSU, H., KATO, T., OHKOHCHI, K. and TAGAMI, H. Plasma Anaphylatoxin Concentrations in Inflammatory Skin Diseases. Tohoku J. exp. Med., 1987, 151(2), 245-252-To study the possible involvement of the complement system in inflammatory skin disorders, we measured the concentrations of C3a and C4a anaphylatoxins in the peripheral blood of 148 patients with various inflammatory skin disorders and 48 healthy control subjects by radioimmunoassay. Significant increases in mean levels of both C3a and C4a anaphylotoxins were found in 59 patients with psoriasis. Remarkable increases in both C3a and C4a anaphylatoxins were also noted in some patients with leukocytoclastic vasculitis, urticarial vasculitis or unspecified toxic erythema. On the other hand, elevation of C4a alone was noted in a case of systemic lupus erythematosus. In contrast, using the mean of the normal control ±2S.D., no significant anaphylatoxin elevation was found in 16 patients with pustulosis palmaris et plantaris, 7 with pityriasis rosea, 3 with erythema multiforme, and 3 with erythema nodosum or autoimmune bullous dermatoses.View full abstractDownload PDF (681K)
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