Abstract
FUNAKOSHI, A., SCHTEINGART, D.E. and VINIK, A.I. Effect of Insulin on Motilin Release in Man. Tohoku J. exp. Med., 1987, 152 (3), 247-251 The effect of insulin on motilin release was investigated by use of the euglycemic glucose clamp technique. By use of this technique plasma glucose concentration was maintained constant at 80-90mg/100ml, and plasma insulin immunoreactivity (IRI) was increased from 15±6μU/ml to 171±22μU/ml in 10min, and remained at this level for 2hr. Plasma motilin like immunoreactivity (MLI) concentration decreased within 10min from 199±36pg/ml to 120±28pg/ml and remained low during the course of study. A significant negative correlation between MLI and IRI concentrations (r=-0.72, p<0.01) was observed. The present results indicate that the suppressive effect of insulin on motilin release is a direct action of insulin and is not mediated by glucose.
