The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Localization of nRNP Antigen in Mammalian Cells Stained with Peroxidase-Labelled IgG Fraction of Anti-nRNP Antibody Obtained from a Patient with Mixed Connective Tissue Disease (MCTD)
KOICHI SAITO, KEIICHI SAGAWA, TOMOE NISHIMAKI, TAKAO MORITO, KIROSHI YOSHIDA, REIJI KASUKAWA
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キーワード: nucelar ribonucleo protein antigen, U1-RNA, anterior horn cells, mixed connective tissue disease, immunohistochemistry
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1987 年 153 巻 1 号 p. 21-26

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SAITO, K., SAGAWA, K., NISHIMAKI, T., MORITO, T., YOSHIDA, H. and KASUKAWA, R. Localization of nRNP Antigen in Mammalian Cells Stained with Peroxidase-Labelled IgG Fraction of Anti-nRNP Antibody Obtained from a Patient with Mixed Connective Tissue Disease (MCTD). Tohoku J. exp. Med., 1987, 153 (1), 21-26 - The peroxidase-labelled IgG fraction of anti-nRNP antibody obtained from a MCTD patient stained the nuclei of almost any kind of cells of man and rat. In addition, the cytoplasma of anterior horn cells of the rat spinal cord was exclusively reacted with this antibody. Both cytoplasmic and nuclear staining of the anterior horn cells were reduced after treatment of tissue sections with RNase.

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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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