1988 Volume 154 Issue 1 Pages 1-9
FUNAKOSHI, A., MIYASAKA, K., SHINOZAKI, H., KITANI, K., SUGIYAMA, N. and YAJIMA, H. Effects of Human Pancreatic Polypeptide on Exocrine Pancreatic Function in Conscious Rats. Tohoku J. exp. Med., 1988, 154 (1), 1-9 - The effect of newly synthesized human pancreatic polypeptide (hPP) on pancreatic secretion stimulated by a diversion of bile-pancreatic juice (BPJ) from the intestine, and plasma hPP concentration were examined in conscious rats. Exogenous hPP infusion (1, 10μg/kg/hr) inhibited pancreatic protein, bicarbonate and fluid outputs during BPJ diversion in a dose-dependent manner. During 1 and 10μg/ kg/hr hPP infusion plasma hPP immunoreactivity increased to 369±22.9 and 1, 125±90.2pg/ml, respectively. These results suggest that newly synthesized hPP has an inhibitory activity on exocrine function of the pancreas.
