Abstract
FUNAKOSHI, A., MIYASAKA, K., SHINOZAKI, H., KITANI, K., SUGIYAMA, N. and YAJIMA, H. Effects of Human Pancreatic Polypeptide on Exocrine Pancreatic Function in Conscious Rats. Tohoku J. exp. Med., 1988, 154 (1), 1-9 - The effect of newly synthesized human pancreatic polypeptide (hPP) on pancreatic secretion stimulated by a diversion of bile-pancreatic juice (BPJ) from the intestine, and plasma hPP concentration were examined in conscious rats. Exogenous hPP infusion (1, 10μg/kg/hr) inhibited pancreatic protein, bicarbonate and fluid outputs during BPJ diversion in a dose-dependent manner. During 1 and 10μg/ kg/hr hPP infusion plasma hPP immunoreactivity increased to 369±22.9 and 1, 125±90.2pg/ml, respectively. These results suggest that newly synthesized hPP has an inhibitory activity on exocrine function of the pancreas.
