The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Absence of IL-1 Inhibitor in Psoriatic Scale Extracts
TADASHI TERUIRYUJI SUZUKIKATSUO KUMAGAIHIDEAKI TAKEMATSUTAIZO KATOHACHIRO TAGAMI
著者情報
キーワード: psoriatic scale, IL-1 inhibitor
ジャーナル フリー

1988 年 156 巻 2 号 p. 149-156

詳細
抄録
In the previous report we found that IL-1-like activity in horny tissue extracts from patients with psoriasis vulgaris and related sterile pustular dermatoses was remarkably low as compared to that in orthokeratotic horny tissue extracts prepared from non-inflammatory skin. In this report we studied the inhibitory activity of lesional horny tissue extracts from three psoriatics on recombinant IL-1-induced thymocyte proliferation in order to search for a possible coexistence of substances which may inhibit thymocyte proliferation. However, we failed to demonstrate any remarkable IL-1 inhibitory activity in each fraction after gel filtration high-performance liquid chromatography of the psoriatic scale extracts or in that of extracts from the plantar callus. We conclude that IL-1 stores are decreased in the pathologic horny layers of psoriatic lesions.
著者関連情報
© Tohoku University Medical Press
前の記事 次の記事
feedback
Top